Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy

Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, Suran Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell–derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired phenolic adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability—a critically important component for translation to clinical settings.

Original languageEnglish
Article number1903863
JournalAdvanced Functional Materials
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Hyaluronic acid
Hydrogel
Hyaluronic Acid
shelves
Hydrogels
therapy
delivery
drugs
Tissue
Drug delivery
acids
availability
stem cells
adhesives
tapes
Availability
Stem cells
Tapes
Adhesives
wound healing

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Shin, Jisoo ; Choi, Soojeong ; Kim, Jung Hyun ; Cho, Jung Ho ; Jin, Yoonhee ; Kim, Suran ; Min, Sungjin ; Kim, Su Kyeom ; Choi, Donghoon ; Cho, Seung Woo. / Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy. In: Advanced Functional Materials. 2019.
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Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy. / Shin, Jisoo; Choi, Soojeong; Kim, Jung Hyun; Cho, Jung Ho; Jin, Yoonhee; Kim, Suran; Min, Sungjin; Kim, Su Kyeom; Choi, Donghoon; Cho, Seung Woo.

In: Advanced Functional Materials, 01.01.2019.

Research output: Contribution to journalArticle

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