Titanized or zirconized porous silica modified with a cellulose derivative as new chiral stationary phases

Jin Seo You, Won Kang Gyoung, Tae Park Seong, Myeonghee Moon, Hag Park Jung, Jo Cheong Won

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Spherical porous silica supports modified with titanium or zirconium alkoxides were prepared, and allyl groups were chemically attached to the titanized or zirconized silica supports, and the product was cross-polymerized with a double bond containing cellulose derivative to yield new CSPs (chiral stationary phases). Magic angle spinning 13C solid state NMR and elemental analysis were used to characterize the CSPs. The performances of the chiral stationary phases were examined in comparison with a conventional chiral stationary phase. Spherical porous silica particles modified with 3,5-dimethylphenylcarbamate of cellulose were prepared and used as the conventional chiral stationary phase. Chromatographic data were collected for a few pairs of enantionmers in heptane/2-propanol mixed solvents of various compositions with the three chiral columns and the results were comparatively studied. The separation performance of the chrial phase made of the titanized silica was better than the others, and the separation performance of the chiral phase of the zirconized silica was comparable to that of the conventional chiral phase. The superiority of titanized silica over bare or zirconized silica in chiral separation seemed to be owing to the better yield of crosslinking (monitored by increase of carbon load) for titanized silica than for the others.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume28
Issue number6
DOIs
Publication statusPublished - 2007 Jun 20

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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