Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients

doyoung kim, Jong Won Choi, Hye Young Chang, Seungup Kim, Hana Park, Yong Han Paik, Ja Kyung Kim, SangHoon Ahn, Junyong Park, Sook In Chung, Kwan Sik Lee, KwangHyub Han, Chae Yoon Chon

Research output: Contribution to journalArticle

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Abstract

Background/ Aims: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection. Methodology: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing. Results: Mean age differed significantly between groups (group I, 34.8±11.4 years; group II 51.0±8.9 years; p<0.001), whereas the proportion of males (80.2% vs. 73.4%, respectively; p=0.085) and hepatitis B e antigen-positive patients (40.7% vs. 43.6%, respectively; p=0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9±138.5 IU/L) than in group II (56.6±70.7 IU/L, p=0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients. Conclusions: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis.

Original languageEnglish
Pages (from-to)1351-1355
Number of pages5
JournalHepato-Gastroenterology
Volume57
Issue number104
Publication statusPublished - 2010 Nov 1

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Toll-Like Receptors
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Liver Cirrhosis
Alleles
Toll-Like Receptor 2
Hepatitis B e Antigens
Alanine Transaminase
Innate Immunity
Liver
Serum
Population
Genes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

kim, doyoung ; Choi, Jong Won ; Chang, Hye Young ; Kim, Seungup ; Park, Hana ; Paik, Yong Han ; Kim, Ja Kyung ; Ahn, SangHoon ; Park, Junyong ; Chung, Sook In ; Lee, Kwan Sik ; Han, KwangHyub ; Chon, Chae Yoon. / Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients. In: Hepato-Gastroenterology. 2010 ; Vol. 57, No. 104. pp. 1351-1355.
@article{41d62935966d4b149a856c90aff1c794,
title = "Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients",
abstract = "Background/ Aims: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection. Methodology: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing. Results: Mean age differed significantly between groups (group I, 34.8±11.4 years; group II 51.0±8.9 years; p<0.001), whereas the proportion of males (80.2{\%} vs. 73.4{\%}, respectively; p=0.085) and hepatitis B e antigen-positive patients (40.7{\%} vs. 43.6{\%}, respectively; p=0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9±138.5 IU/L) than in group II (56.6±70.7 IU/L, p=0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients. Conclusions: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis.",
author = "doyoung kim and Choi, {Jong Won} and Chang, {Hye Young} and Seungup Kim and Hana Park and Paik, {Yong Han} and Kim, {Ja Kyung} and SangHoon Ahn and Junyong Park and Chung, {Sook In} and Lee, {Kwan Sik} and KwangHyub Han and Chon, {Chae Yoon}",
year = "2010",
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kim, D, Choi, JW, Chang, HY, Kim, S, Park, H, Paik, YH, Kim, JK, Ahn, S, Park, J, Chung, SI, Lee, KS, Han, K & Chon, CY 2010, 'Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients', Hepato-Gastroenterology, vol. 57, no. 104, pp. 1351-1355.

Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients. / kim, doyoung; Choi, Jong Won; Chang, Hye Young; Kim, Seungup; Park, Hana; Paik, Yong Han; Kim, Ja Kyung; Ahn, SangHoon; Park, Junyong; Chung, Sook In; Lee, Kwan Sik; Han, KwangHyub; Chon, Chae Yoon.

In: Hepato-Gastroenterology, Vol. 57, No. 104, 01.11.2010, p. 1351-1355.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients

AU - kim, doyoung

AU - Choi, Jong Won

AU - Chang, Hye Young

AU - Kim, Seungup

AU - Park, Hana

AU - Paik, Yong Han

AU - Kim, Ja Kyung

AU - Ahn, SangHoon

AU - Park, Junyong

AU - Chung, Sook In

AU - Lee, Kwan Sik

AU - Han, KwangHyub

AU - Chon, Chae Yoon

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background/ Aims: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection. Methodology: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing. Results: Mean age differed significantly between groups (group I, 34.8±11.4 years; group II 51.0±8.9 years; p<0.001), whereas the proportion of males (80.2% vs. 73.4%, respectively; p=0.085) and hepatitis B e antigen-positive patients (40.7% vs. 43.6%, respectively; p=0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9±138.5 IU/L) than in group II (56.6±70.7 IU/L, p=0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients. Conclusions: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis.

AB - Background/ Aims: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection. Methodology: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing. Results: Mean age differed significantly between groups (group I, 34.8±11.4 years; group II 51.0±8.9 years; p<0.001), whereas the proportion of males (80.2% vs. 73.4%, respectively; p=0.085) and hepatitis B e antigen-positive patients (40.7% vs. 43.6%, respectively; p=0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9±138.5 IU/L) than in group II (56.6±70.7 IU/L, p=0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients. Conclusions: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis.

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M3 - Article

VL - 57

SP - 1351

EP - 1355

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 104

ER -