Abstract
We demonstrate here that rationally designed block copolypeptides based on poly(L-arginine) and β-sheet peptides can form toroidal nanostructures. In aqueous solution, we found that 1D nanoribbons roll up and connect in an end-to-end fashion under charge-balanced conditions, resulting in the formation of barrel-like toroidal nanostructures. Toroidal diameter was highly uniform (10 nm), indicating that there is a preferred geometrical packing requirement for toroid formation. Our results demonstrate that, when suitably designed, β-sheet nanostructures can be manipulated to form more complex 2D nanostructures. This finding offers new opportunities not only for the fabrication of more sophisticated peptide-based nanobiomaterials, but also for understanding and inhibiting protein misfolding diseases. Block copolypeptides based on poly(L-arginine) and β-sheet peptide, can form toroidal nanostructures in aqueous solution by rolling-up of 1D nanoribbon and end-to-end connection of the nanoribbon under charge balanced condition. This finding offer new opportunity not only for fabricating more sophisticated peptide-based nanobiomaterials, but for understanding protein misfolding mechanism also.
Original language | English |
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Pages (from-to) | 191-196 |
Number of pages | 6 |
Journal | Macromolecular rapid communications |
Volume | 32 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 Jan 17 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry