Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke

Tae Jin Song, Jinkwon Kim, Dongbeom Song, Joonsang Yoo, Hye Sun Lee, Yong Jae Kim, Hyo Suk Nam, Jihoe Heo, Young Dae Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background and Purpose The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the total burden or severity of CSVD. We investigated whether the total CSVD score is associated with long-term outcomes during follow-up in patients with acute ischemic stroke. Methods In total, 1,096 consecutive patients with acute ischemic stroke who underwent brain magnetic resonance imaging were enrolled. We calculated the total CSVD score for each patient after determining the burden of cerebral microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs). We recorded the date and cause of death for all of the patients using data from the Korean National Statistical Office. We compared the long-term mortality rate with the total CSVD score using Cox proportional-hazards models. Results CMBs were found in 26.8% of the subjects (294/1,096), HWHs in 16.4% (180/1,096), HPVSs in 19.3% (211/1,096), and ALIs in 38.0% (416/1,096). After adjusting for age, sex, and variables that were significant at p<0.1 in the univariate analysis, the total CSVD score was independently associated with long-term death from all causes [hazard ratio (HR)=1.18 per point, 95% confidence interval (CI)=1.07–1.30], ischemic stroke (HR=1.20 per point, 95% CI=1.01–1.42), and hemorrhagic stroke (HR=2.05 per point, 95% CI=1.30– 3.22), but not with fatal cardiovascular events (HR=1.17 per point, 95% CI=0.82–1.67). Conclusions The total CSVD score is a potential imaging biomarker for predicting mortality during follow-up in patients with acute ischemic stroke.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalJournal of Clinical Neurology (Korea)
Volume13
Issue number2
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

Cerebral Small Vessel Diseases
Stroke
Mortality
Confidence Intervals
Lacunar Stroke
Cause of Death
Proportional Hazards Models
Biomarkers
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Song, Tae Jin ; Kim, Jinkwon ; Song, Dongbeom ; Yoo, Joonsang ; Lee, Hye Sun ; Kim, Yong Jae ; Nam, Hyo Suk ; Heo, Jihoe ; Kim, Young Dae. / Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke. In: Journal of Clinical Neurology (Korea). 2017 ; Vol. 13, No. 2. pp. 187-195.
@article{43eda0aaeadc47a99cd2a6b5a3f85e8a,
title = "Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke",
abstract = "Background and Purpose The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the total burden or severity of CSVD. We investigated whether the total CSVD score is associated with long-term outcomes during follow-up in patients with acute ischemic stroke. Methods In total, 1,096 consecutive patients with acute ischemic stroke who underwent brain magnetic resonance imaging were enrolled. We calculated the total CSVD score for each patient after determining the burden of cerebral microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs). We recorded the date and cause of death for all of the patients using data from the Korean National Statistical Office. We compared the long-term mortality rate with the total CSVD score using Cox proportional-hazards models. Results CMBs were found in 26.8{\%} of the subjects (294/1,096), HWHs in 16.4{\%} (180/1,096), HPVSs in 19.3{\%} (211/1,096), and ALIs in 38.0{\%} (416/1,096). After adjusting for age, sex, and variables that were significant at p<0.1 in the univariate analysis, the total CSVD score was independently associated with long-term death from all causes [hazard ratio (HR)=1.18 per point, 95{\%} confidence interval (CI)=1.07–1.30], ischemic stroke (HR=1.20 per point, 95{\%} CI=1.01–1.42), and hemorrhagic stroke (HR=2.05 per point, 95{\%} CI=1.30– 3.22), but not with fatal cardiovascular events (HR=1.17 per point, 95{\%} CI=0.82–1.67). Conclusions The total CSVD score is a potential imaging biomarker for predicting mortality during follow-up in patients with acute ischemic stroke.",
author = "Song, {Tae Jin} and Jinkwon Kim and Dongbeom Song and Joonsang Yoo and Lee, {Hye Sun} and Kim, {Yong Jae} and Nam, {Hyo Suk} and Jihoe Heo and Kim, {Young Dae}",
year = "2017",
month = "4",
day = "1",
doi = "10.3988/jcn.2017.13.2.187",
language = "English",
volume = "13",
pages = "187--195",
journal = "Journal of Clinical Neurology (Korea)",
issn = "1738-6586",
publisher = "Korean Neurological Association",
number = "2",

}

Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke. / Song, Tae Jin; Kim, Jinkwon; Song, Dongbeom; Yoo, Joonsang; Lee, Hye Sun; Kim, Yong Jae; Nam, Hyo Suk; Heo, Jihoe; Kim, Young Dae.

In: Journal of Clinical Neurology (Korea), Vol. 13, No. 2, 01.04.2017, p. 187-195.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke

AU - Song, Tae Jin

AU - Kim, Jinkwon

AU - Song, Dongbeom

AU - Yoo, Joonsang

AU - Lee, Hye Sun

AU - Kim, Yong Jae

AU - Nam, Hyo Suk

AU - Heo, Jihoe

AU - Kim, Young Dae

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background and Purpose The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the total burden or severity of CSVD. We investigated whether the total CSVD score is associated with long-term outcomes during follow-up in patients with acute ischemic stroke. Methods In total, 1,096 consecutive patients with acute ischemic stroke who underwent brain magnetic resonance imaging were enrolled. We calculated the total CSVD score for each patient after determining the burden of cerebral microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs). We recorded the date and cause of death for all of the patients using data from the Korean National Statistical Office. We compared the long-term mortality rate with the total CSVD score using Cox proportional-hazards models. Results CMBs were found in 26.8% of the subjects (294/1,096), HWHs in 16.4% (180/1,096), HPVSs in 19.3% (211/1,096), and ALIs in 38.0% (416/1,096). After adjusting for age, sex, and variables that were significant at p<0.1 in the univariate analysis, the total CSVD score was independently associated with long-term death from all causes [hazard ratio (HR)=1.18 per point, 95% confidence interval (CI)=1.07–1.30], ischemic stroke (HR=1.20 per point, 95% CI=1.01–1.42), and hemorrhagic stroke (HR=2.05 per point, 95% CI=1.30– 3.22), but not with fatal cardiovascular events (HR=1.17 per point, 95% CI=0.82–1.67). Conclusions The total CSVD score is a potential imaging biomarker for predicting mortality during follow-up in patients with acute ischemic stroke.

AB - Background and Purpose The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the total burden or severity of CSVD. We investigated whether the total CSVD score is associated with long-term outcomes during follow-up in patients with acute ischemic stroke. Methods In total, 1,096 consecutive patients with acute ischemic stroke who underwent brain magnetic resonance imaging were enrolled. We calculated the total CSVD score for each patient after determining the burden of cerebral microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs). We recorded the date and cause of death for all of the patients using data from the Korean National Statistical Office. We compared the long-term mortality rate with the total CSVD score using Cox proportional-hazards models. Results CMBs were found in 26.8% of the subjects (294/1,096), HWHs in 16.4% (180/1,096), HPVSs in 19.3% (211/1,096), and ALIs in 38.0% (416/1,096). After adjusting for age, sex, and variables that were significant at p<0.1 in the univariate analysis, the total CSVD score was independently associated with long-term death from all causes [hazard ratio (HR)=1.18 per point, 95% confidence interval (CI)=1.07–1.30], ischemic stroke (HR=1.20 per point, 95% CI=1.01–1.42), and hemorrhagic stroke (HR=2.05 per point, 95% CI=1.30– 3.22), but not with fatal cardiovascular events (HR=1.17 per point, 95% CI=0.82–1.67). Conclusions The total CSVD score is a potential imaging biomarker for predicting mortality during follow-up in patients with acute ischemic stroke.

UR - http://www.scopus.com/inward/record.url?scp=85017520512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017520512&partnerID=8YFLogxK

U2 - 10.3988/jcn.2017.13.2.187

DO - 10.3988/jcn.2017.13.2.187

M3 - Article

VL - 13

SP - 187

EP - 195

JO - Journal of Clinical Neurology (Korea)

JF - Journal of Clinical Neurology (Korea)

SN - 1738-6586

IS - 2

ER -