Total necrosis of hepatocellular carcinoma due to spontaneous occlusion of feeding artery

Sang Cheol Lee, Hye Won Chung, Jae Bock Chung, Young Nyun Park, Sang Hoon Ahn, Seung Woo Park, Chae Yoon Chun, Young Myoung Moon, Jin Kyung Kang, In Suh Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Spontaneous total necrosis of hepatocellular carcinoma is extremely rare, with only 15 cases reported to date in the English literature, and the involved mechanism remains unresolved. This paper describes a case of spontaneous necrosis of hepatocellular carcinoma in a 70-year-old man with chronic hepatitis. The patient suffered epigastric pain on admission and computed tomography revealed a 4 cm mass with low density in the left lobe of the liver. Fine needle aspiration biopsy revealed a few scattered, naked and irregular nuclei exhibiting nuclear hyperchromasia in the dirty necrotic background, a finding highly suggestive of malignancy. The lobectomized liver revealed a 3.5 cm, well encapsulated, round, and nearly totally necrotic mass. On microscopic examination, the tumor was found to be composed of thick trabeculae of necrotic tumor cells, supporting the diagnosis of hepatocellular carcinoma. After surgery and throughout 13 months of follow up the patient has recovered well.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalYonsei medical journal
Issue number1
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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