Total synthesis of (±)-homoepibatidine (2), which contains the 8-azabicyclo[3.2.1] octane ring system, was achieved by using palladium-catalyzed Heck-type coupling reaction from 3.
Bibliographical noteFunding Information:
Financial support from Ministry of Health and Welfare (HWP-96-D-1-0006) is gratefully acknowledged.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
- Organic Chemistry