TY - JOUR
T1 - Towards disposable lab-on-a-chip
T2 - Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection
AU - Wang, Joseph
AU - Pumera, Martin
AU - Chatrathi, Madhu Prakash
AU - Escarpa, Alberto
AU - Konrad, Renate
AU - Griebel, Anja
AU - Drner, Wolfgang
AU - Lwe, Holger
PY - 2002
Y1 - 2002
N2 - A fully disposable microanalytical device based on combination of poly(methylmethacrylate) (PMMA) capillary electrophoresis microchips and thick-film electrochemical detector strips is described. Variables influencing the separation efficiency and amperometric response, including separation voltage or detection potential are assessed and optimized. The versatility, simplicity and low-cost advantages of the new design are coupled to an attractive analytical performance, with good precision (relative standard deviation RSD = 1.68% for n = 10). Applicability for assays of mixtures of hydrazine, phenolic compounds, and catecholamines is demonstrated. Such coupling of low-cost PMMA-based microchips with thick-film electrochemical detectors holds great promise for mass production of single-use micrototal analytical systems.
AB - A fully disposable microanalytical device based on combination of poly(methylmethacrylate) (PMMA) capillary electrophoresis microchips and thick-film electrochemical detector strips is described. Variables influencing the separation efficiency and amperometric response, including separation voltage or detection potential are assessed and optimized. The versatility, simplicity and low-cost advantages of the new design are coupled to an attractive analytical performance, with good precision (relative standard deviation RSD = 1.68% for n = 10). Applicability for assays of mixtures of hydrazine, phenolic compounds, and catecholamines is demonstrated. Such coupling of low-cost PMMA-based microchips with thick-film electrochemical detectors holds great promise for mass production of single-use micrototal analytical systems.
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U2 - 10.1002/1522-2683(200202)23:4<596::AID-ELPS596>3.0.CO;2-C
DO - 10.1002/1522-2683(200202)23:4<596::AID-ELPS596>3.0.CO;2-C
M3 - Article
C2 - 11870771
AN - SCOPUS:0036123034
SN - 0173-0835
VL - 23
SP - 596
EP - 601
JO - Electrophoresis
JF - Electrophoresis
IS - 4
ER -