Towards disposable lab-on-a-chip: Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection

Joseph Wang, Martin Pumera, Madhu Prakash Chatrathi, Alberto Escarpa, Renate Konrad, Anja Griebel, Wolfgang Drner, Holger Lwe

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

A fully disposable microanalytical device based on combination of poly(methylmethacrylate) (PMMA) capillary electrophoresis microchips and thick-film electrochemical detector strips is described. Variables influencing the separation efficiency and amperometric response, including separation voltage or detection potential are assessed and optimized. The versatility, simplicity and low-cost advantages of the new design are coupled to an attractive analytical performance, with good precision (relative standard deviation RSD = 1.68% for n = 10). Applicability for assays of mixtures of hydrazine, phenolic compounds, and catecholamines is demonstrated. Such coupling of low-cost PMMA-based microchips with thick-film electrochemical detectors holds great promise for mass production of single-use micrototal analytical systems.

Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalElectrophoresis
Volume23
Issue number4
DOIs
Publication statusPublished - 2002 Mar 27

Fingerprint

Microchip Electrophoresis
Methylmethacrylate
Lab-on-a-chip
hydrazine
Electrophoresis
Thick films
Detectors
Costs and Cost Analysis
Capillary electrophoresis
Equipment and Supplies
Capillary Electrophoresis
Catecholamines
Costs
Assays
Electric potential

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

Wang, Joseph ; Pumera, Martin ; Chatrathi, Madhu Prakash ; Escarpa, Alberto ; Konrad, Renate ; Griebel, Anja ; Drner, Wolfgang ; Lwe, Holger. / Towards disposable lab-on-a-chip : Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection. In: Electrophoresis. 2002 ; Vol. 23, No. 4. pp. 596-601.
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Towards disposable lab-on-a-chip : Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection. / Wang, Joseph; Pumera, Martin; Chatrathi, Madhu Prakash; Escarpa, Alberto; Konrad, Renate; Griebel, Anja; Drner, Wolfgang; Lwe, Holger.

In: Electrophoresis, Vol. 23, No. 4, 27.03.2002, p. 596-601.

Research output: Contribution to journalArticle

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AU - Wang, Joseph

AU - Pumera, Martin

AU - Chatrathi, Madhu Prakash

AU - Escarpa, Alberto

AU - Konrad, Renate

AU - Griebel, Anja

AU - Drner, Wolfgang

AU - Lwe, Holger

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