Towards disposable lab-on-a-chip: Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection

Joseph Wang, Martin Pumera, Madhu Prakash Chatrathi, Alberto Escarpa, Renate Konrad, Anja Griebel, Wolfgang Drner, Holger Lwe

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

A fully disposable microanalytical device based on combination of poly(methylmethacrylate) (PMMA) capillary electrophoresis microchips and thick-film electrochemical detector strips is described. Variables influencing the separation efficiency and amperometric response, including separation voltage or detection potential are assessed and optimized. The versatility, simplicity and low-cost advantages of the new design are coupled to an attractive analytical performance, with good precision (relative standard deviation RSD = 1.68% for n = 10). Applicability for assays of mixtures of hydrazine, phenolic compounds, and catecholamines is demonstrated. Such coupling of low-cost PMMA-based microchips with thick-film electrochemical detectors holds great promise for mass production of single-use micrototal analytical systems.

Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalElectrophoresis
Volume23
Issue number4
DOIs
Publication statusPublished - 2002 Mar 27

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Towards disposable lab-on-a-chip: Poly(methylmethacrylate) microchip electrophoresis device with electrochemical detection'. Together they form a unique fingerprint.

  • Cite this