TP53BP2 locus is associated with gastric cancer susceptibility

Hyoungseok Ju, Kyung A. Lee, Misuk Yang, Hee Jin Kim, Changsoo Paul Kang, Tae Sung Sohn, Jong Chul Rhee, Changwon Kang, Jong Won Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We investigated the association of the TP53BP2 locus with gastric cancer susceptibility in a Korean population. We assayed 9 single nucleotide polymorphisms (SNP) in an 82.5 kb region that included the TP53BP2 locus in 233 male gastric cancer patients and 390 unaffected healthy male controls. The allelic frequencies of 4 SNP within TP53BP2, g.206692C>T, g.198267A>T, g.164895G>A and g.152389A>T, differed significantly between cases and controls (p ≤ 0.0376). When compared to carriers of non-risk alleles, individuals homozygotic for each of the risk alleles had a 50% increase in risk of gastric cancer (age-adjusted odds ratio [OR] ≥ 1.48; p ≤ 0.0371). Furthermore, these 4 significantly associated SNP were in strong linkage disequilibrium (r2 ≥ 0.51). Haplotype analysis showed that individuals with the CAGA haplotype, consisting of the risk alleles at each SNP, had a 1.55-fold higher risk for gastric cancer than individuals with the haplotype TTAT, consisting of the non-risk alleles at each SNP (OR = 1.55; 95% confidence interval [CI] = 1.13-2.14; p = 0.00705). Two other SNP were not polymorphic in the study subjects, whereas the other 3 SNP, located toward the outside of the TP53BP2 locus, were not associated with gastric cancer susceptibility. Although the location of the pathogenic variant is not yet known, our results suggest that the TP53BP2 locus is associated with susceptibility to gastric cancer in the Korean population.

Original languageEnglish
Pages (from-to)957-960
Number of pages4
JournalInternational Journal of Cancer
Volume117
Issue number6
DOIs
Publication statusPublished - 2005 Dec 20

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Stomach Neoplasms
Single Nucleotide Polymorphism
Alleles
Haplotypes
Odds Ratio
Linkage Disequilibrium
Population
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ju, H., Lee, K. A., Yang, M., Kim, H. J., Kang, C. P., Sohn, T. S., ... Kim, J. W. (2005). TP53BP2 locus is associated with gastric cancer susceptibility. International Journal of Cancer, 117(6), 957-960. https://doi.org/10.1002/ijc.21281
Ju, Hyoungseok ; Lee, Kyung A. ; Yang, Misuk ; Kim, Hee Jin ; Kang, Changsoo Paul ; Sohn, Tae Sung ; Rhee, Jong Chul ; Kang, Changwon ; Kim, Jong Won. / TP53BP2 locus is associated with gastric cancer susceptibility. In: International Journal of Cancer. 2005 ; Vol. 117, No. 6. pp. 957-960.
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Ju, H, Lee, KA, Yang, M, Kim, HJ, Kang, CP, Sohn, TS, Rhee, JC, Kang, C & Kim, JW 2005, 'TP53BP2 locus is associated with gastric cancer susceptibility', International Journal of Cancer, vol. 117, no. 6, pp. 957-960. https://doi.org/10.1002/ijc.21281

TP53BP2 locus is associated with gastric cancer susceptibility. / Ju, Hyoungseok; Lee, Kyung A.; Yang, Misuk; Kim, Hee Jin; Kang, Changsoo Paul; Sohn, Tae Sung; Rhee, Jong Chul; Kang, Changwon; Kim, Jong Won.

In: International Journal of Cancer, Vol. 117, No. 6, 20.12.2005, p. 957-960.

Research output: Contribution to journalArticle

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T1 - TP53BP2 locus is associated with gastric cancer susceptibility

AU - Ju, Hyoungseok

AU - Lee, Kyung A.

AU - Yang, Misuk

AU - Kim, Hee Jin

AU - Kang, Changsoo Paul

AU - Sohn, Tae Sung

AU - Rhee, Jong Chul

AU - Kang, Changwon

AU - Kim, Jong Won

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N2 - We investigated the association of the TP53BP2 locus with gastric cancer susceptibility in a Korean population. We assayed 9 single nucleotide polymorphisms (SNP) in an 82.5 kb region that included the TP53BP2 locus in 233 male gastric cancer patients and 390 unaffected healthy male controls. The allelic frequencies of 4 SNP within TP53BP2, g.206692C>T, g.198267A>T, g.164895G>A and g.152389A>T, differed significantly between cases and controls (p ≤ 0.0376). When compared to carriers of non-risk alleles, individuals homozygotic for each of the risk alleles had a 50% increase in risk of gastric cancer (age-adjusted odds ratio [OR] ≥ 1.48; p ≤ 0.0371). Furthermore, these 4 significantly associated SNP were in strong linkage disequilibrium (r2 ≥ 0.51). Haplotype analysis showed that individuals with the CAGA haplotype, consisting of the risk alleles at each SNP, had a 1.55-fold higher risk for gastric cancer than individuals with the haplotype TTAT, consisting of the non-risk alleles at each SNP (OR = 1.55; 95% confidence interval [CI] = 1.13-2.14; p = 0.00705). Two other SNP were not polymorphic in the study subjects, whereas the other 3 SNP, located toward the outside of the TP53BP2 locus, were not associated with gastric cancer susceptibility. Although the location of the pathogenic variant is not yet known, our results suggest that the TP53BP2 locus is associated with susceptibility to gastric cancer in the Korean population.

AB - We investigated the association of the TP53BP2 locus with gastric cancer susceptibility in a Korean population. We assayed 9 single nucleotide polymorphisms (SNP) in an 82.5 kb region that included the TP53BP2 locus in 233 male gastric cancer patients and 390 unaffected healthy male controls. The allelic frequencies of 4 SNP within TP53BP2, g.206692C>T, g.198267A>T, g.164895G>A and g.152389A>T, differed significantly between cases and controls (p ≤ 0.0376). When compared to carriers of non-risk alleles, individuals homozygotic for each of the risk alleles had a 50% increase in risk of gastric cancer (age-adjusted odds ratio [OR] ≥ 1.48; p ≤ 0.0371). Furthermore, these 4 significantly associated SNP were in strong linkage disequilibrium (r2 ≥ 0.51). Haplotype analysis showed that individuals with the CAGA haplotype, consisting of the risk alleles at each SNP, had a 1.55-fold higher risk for gastric cancer than individuals with the haplotype TTAT, consisting of the non-risk alleles at each SNP (OR = 1.55; 95% confidence interval [CI] = 1.13-2.14; p = 0.00705). Two other SNP were not polymorphic in the study subjects, whereas the other 3 SNP, located toward the outside of the TP53BP2 locus, were not associated with gastric cancer susceptibility. Although the location of the pathogenic variant is not yet known, our results suggest that the TP53BP2 locus is associated with susceptibility to gastric cancer in the Korean population.

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