Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim, Kyung Chul Yoon, Kyoung Yul Seo, Choun Ki Joo, Virender Sangwan, Varsha Rathi, Sayan Basu, Almas Shamaila, Hyo Seok Lee, Sangchul Yoon, Chie Sotozono, José Álvaro Pereira Gomes, Katsushi Tokunaga, Shigeru Kinoshita

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Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

Original languageEnglish
Article number5981
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Aug 7

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Stevens-Johnson Syndrome
HLA-A Antigens
HLA-B Antigens
Medicine
Multi-Ingredient Cold, Flu, and Allergy Medications
Ethnic Groups
Pharmaceutical Preparations
Population
Mucous Membrane
Anti-Inflammatory Agents
Skin

All Science Journal Classification (ASJC) codes

  • General

Cite this

Ueta, Mayumi ; Kannabiran, Chitra ; Wakamatsu, Tais Hitomi ; Kim, Mee Kum ; Yoon, Kyung Chul ; Seo, Kyoung Yul ; Joo, Choun Ki ; Sangwan, Virender ; Rathi, Varsha ; Basu, Sayan ; Shamaila, Almas ; Lee, Hyo Seok ; Yoon, Sangchul ; Sotozono, Chie ; Gomes, José Álvaro Pereira ; Tokunaga, Katsushi ; Kinoshita, Shigeru. / Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. In: Scientific reports. 2014 ; Vol. 4.
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title = "Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications",
abstract = "Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.",
author = "Mayumi Ueta and Chitra Kannabiran and Wakamatsu, {Tais Hitomi} and Kim, {Mee Kum} and Yoon, {Kyung Chul} and Seo, {Kyoung Yul} and Joo, {Choun Ki} and Virender Sangwan and Varsha Rathi and Sayan Basu and Almas Shamaila and Lee, {Hyo Seok} and Sangchul Yoon and Chie Sotozono and Gomes, {Jos{\'e} {\'A}lvaro Pereira} and Katsushi Tokunaga and Shigeru Kinoshita",
year = "2014",
month = "8",
day = "7",
doi = "10.1038/srep05981",
language = "English",
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journal = "Scientific Reports",
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Ueta, M, Kannabiran, C, Wakamatsu, TH, Kim, MK, Yoon, KC, Seo, KY, Joo, CK, Sangwan, V, Rathi, V, Basu, S, Shamaila, A, Lee, HS, Yoon, S, Sotozono, C, Gomes, JÁP, Tokunaga, K & Kinoshita, S 2014, 'Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications', Scientific reports, vol. 4, 5981. https://doi.org/10.1038/srep05981

Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. / Ueta, Mayumi; Kannabiran, Chitra; Wakamatsu, Tais Hitomi; Kim, Mee Kum; Yoon, Kyung Chul; Seo, Kyoung Yul; Joo, Choun Ki; Sangwan, Virender; Rathi, Varsha; Basu, Sayan; Shamaila, Almas; Lee, Hyo Seok; Yoon, Sangchul; Sotozono, Chie; Gomes, José Álvaro Pereira; Tokunaga, Katsushi; Kinoshita, Shigeru.

In: Scientific reports, Vol. 4, 5981, 07.08.2014.

Research output: Contribution to journalArticle

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AU - Ueta, Mayumi

AU - Kannabiran, Chitra

AU - Wakamatsu, Tais Hitomi

AU - Kim, Mee Kum

AU - Yoon, Kyung Chul

AU - Seo, Kyoung Yul

AU - Joo, Choun Ki

AU - Sangwan, Virender

AU - Rathi, Varsha

AU - Basu, Sayan

AU - Shamaila, Almas

AU - Lee, Hyo Seok

AU - Yoon, Sangchul

AU - Sotozono, Chie

AU - Gomes, José Álvaro Pereira

AU - Tokunaga, Katsushi

AU - Kinoshita, Shigeru

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

AB - Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

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