Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim, Kyung Chul Yoon, Kyoung Yul Seo, Choun Ki Joo, Virender Sangwan, Varsha Rathi, Sayan Basu, Almas Shamaila, Hyo Seok Lee, Sangchul Yoon, Chie Sotozono, José Álvaro Pereira Gomes, Katsushi Tokunaga, Shigeru Kinoshita

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Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

Original languageEnglish
Article number5981
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Aug 7

All Science Journal Classification (ASJC) codes

  • General

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    Ueta, M., Kannabiran, C., Wakamatsu, T. H., Kim, M. K., Yoon, K. C., Seo, K. Y., Joo, C. K., Sangwan, V., Rathi, V., Basu, S., Shamaila, A., Lee, H. S., Yoon, S., Sotozono, C., Gomes, J. Á. P., Tokunaga, K., & Kinoshita, S. (2014). Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Scientific reports, 4, [5981]. https://doi.org/10.1038/srep05981