Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta; Chitra Kannabiran; Tais Hitomi Wakamatsu; Mee Kum Kim; Kyung Chul Yoon; Kyoung Yul Seo; Choun Ki Joo; Virender Sangwan; Varsha Rathi; Sayan Basu; Almas Shamaila; Hyo Seok Lee; Sangchul Yoon; Chie Sotozono; José Álvaro Pereira Gomes; Katsushi Tokunaga; Shigeru Kinoshita

doi:10.1038/srep05981

Trans-ethnic study confirmed independent associations of HLA-A02:06 and HLA-B44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim, Kyung Chul Yoon, Kyoung Yul Seo, Choun Ki Joo, Virender Sangwan, Varsha Rathi, Sayan Basu, Almas Shamaila, Hyo Seok Lee, Sangchul Yoon, Chie Sotozono, José Álvaro Pereira Gomes, Katsushi Tokunaga, Shigeru Kinoshita

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

Original language	English
Article number	5981
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep05981
Publication status	Published - 2014 Aug 7

Bibliographical note

Funding Information:
This work was conducted as part of the BioBank Japan Project supported by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government, and as part of the Promotion Project of Knowledge-Based Industrial Clustering of Okinawa Prefecture. It was supported in part by grants-in-aid for scientific research from the Japanese Ministry of Health, Labour and Welfare, a research grant from the Kyoto Foundation for the Promotion of Medical Science, and the Intramural Research Fund of Kyoto Prefectural University of Medicine. The funding agencies had no role in the study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.

All Science Journal Classification (ASJC) codes

General

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10.1038/srep05981

Cite this

Ueta, M., Kannabiran, C., Wakamatsu, T. H., Kim, M. K., Yoon, K. C., Seo, K. Y., Joo, C. K., Sangwan, V., Rathi, V., Basu, S., Shamaila, A., Lee, H. S., Yoon, S., Sotozono, C., Gomes, J. Á. P., Tokunaga, K., & Kinoshita, S. (2014). Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Scientific reports, 4, [5981]. https://doi.org/10.1038/srep05981

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title = "Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications",

abstract = "Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.",

author = "Mayumi Ueta and Chitra Kannabiran and Wakamatsu, {Tais Hitomi} and Kim, {Mee Kum} and Yoon, {Kyung Chul} and Seo, {Kyoung Yul} and Joo, {Choun Ki} and Virender Sangwan and Varsha Rathi and Sayan Basu and Almas Shamaila and Lee, {Hyo Seok} and Sangchul Yoon and Chie Sotozono and Gomes, {Jos{\'e} {\'A}lvaro Pereira} and Katsushi Tokunaga and Shigeru Kinoshita",

note = "Funding Information: This work was conducted as part of the BioBank Japan Project supported by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government, and as part of the Promotion Project of Knowledge-Based Industrial Clustering of Okinawa Prefecture. It was supported in part by grants-in-aid for scientific research from the Japanese Ministry of Health, Labour and Welfare, a research grant from the Kyoto Foundation for the Promotion of Medical Science, and the Intramural Research Fund of Kyoto Prefectural University of Medicine. The funding agencies had no role in the study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.",

year = "2014",

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day = "7",

doi = "10.1038/srep05981",

language = "English",

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Ueta, M, Kannabiran, C, Wakamatsu, TH, Kim, MK, Yoon, KC, Seo, KY, Joo, CK, Sangwan, V, Rathi, V, Basu, S, Shamaila, A, Lee, HS, Yoon, S, Sotozono, C, Gomes, JÁP, Tokunaga, K & Kinoshita, S 2014, 'Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications', Scientific reports, vol. 4, 5981. https://doi.org/10.1038/srep05981

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T1 - Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

AU - Ueta, Mayumi

AU - Kannabiran, Chitra

AU - Wakamatsu, Tais Hitomi

AU - Kim, Mee Kum

AU - Yoon, Kyung Chul

AU - Seo, Kyoung Yul

AU - Joo, Choun Ki

AU - Sangwan, Virender

AU - Rathi, Varsha

AU - Basu, Sayan

AU - Shamaila, Almas

AU - Lee, Hyo Seok

AU - Yoon, Sangchul

AU - Sotozono, Chie

AU - Gomes, José Álvaro Pereira

AU - Tokunaga, Katsushi

AU - Kinoshita, Shigeru

N1 - Funding Information: This work was conducted as part of the BioBank Japan Project supported by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government, and as part of the Promotion Project of Knowledge-Based Industrial Clustering of Okinawa Prefecture. It was supported in part by grants-in-aid for scientific research from the Japanese Ministry of Health, Labour and Welfare, a research grant from the Kyoto Foundation for the Promotion of Medical Science, and the Intramural Research Fund of Kyoto Prefectural University of Medicine. The funding agencies had no role in the study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.

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