Trans-regulation of syndecan functions by hetero-oligomerization

Youngsil Choi, Mi Jung Kwon, Yangmi Lim, Ji Hye Yun, Weon Tae Lee, Eok Soo Oh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.

Original languageEnglish
Pages (from-to)16943-16953
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
Publication statusPublished - 2015 Jul 3

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Syndecans
Oligomerization
Syndecan-2
Syndecan-4

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Choi, Youngsil ; Kwon, Mi Jung ; Lim, Yangmi ; Yun, Ji Hye ; Lee, Weon Tae ; Oh, Eok Soo. / Trans-regulation of syndecan functions by hetero-oligomerization. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 27. pp. 16943-16953.
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Trans-regulation of syndecan functions by hetero-oligomerization. / Choi, Youngsil; Kwon, Mi Jung; Lim, Yangmi; Yun, Ji Hye; Lee, Weon Tae; Oh, Eok Soo.

In: Journal of Biological Chemistry, Vol. 290, No. 27, 03.07.2015, p. 16943-16953.

Research output: Contribution to journalArticle

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AU - Oh, Eok Soo

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