Trans-regulation of syndecan functions by hetero-oligomerization

Youngsil Choi, Mi Jung Kwon, Yangmi Lim, Ji Hye Yun, Weontae Lee, Eok Soo Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.

Original languageEnglish
Pages (from-to)16943-16953
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
Publication statusPublished - 2015 Jul 3

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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