Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.
Bibliographical notePublisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology