Transcriptional and epigenetic networks in the development and maturation of dendritic cells

Hyoung Pyo Kim, Yeon Su Lee, Jong Hoon Park, Young Joon Kim

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that provide a critical link between the innate and adaptive immune responses. The genetic program required for differentiation of DCs from their hematopoietic precursors is controlled by both cytokines and transcription factors. The signals transduced from cytokines recruit specific transcription factors, enabling the expression of a distinct transcriptome that is required for specification of different DC lineages. The establishment of a distinct transcriptome also depends on chromatin modifications associated with critical cis elements of lineage-specific genes. In this review, recent advances in the understanding of the transcriptional network governing DC lineage specification are summarized, along with current views of the dynamic DC epigenome.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalEpigenomics
Volume5
Issue number2
DOIs
Publication statusPublished - 2013 Apr 1

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

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