Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2

Hyun Jin Kwun, Jae Hwa Lee, Do Sik Min, Kyung Lib Jang

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15 Citations (Scopus)

Abstract

Phospholipase D (PLD) is known to stimulate cell cycle progression and to transform murine fibroblast cells into tumorigenic forms, although the precise mechanisms are not elucidated. In this report, we demonstrated that both PLD1 and PLD2 repressed expression of cyclin-dependent kinase inhibitor p21 gene in an additive manner. The phospholipase activity of PLDs was important for the effect. PLD1 repressed the p21 promoter by decreasing the level of p53, whereas PLD2 via a p53-independent pathway through modulating Sp1 activity. Taken together, we suggest that PLD isozymes stimulate cell growth by repressing expression of p21 gene, which may ultimately lead to carcinogenesis.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalFEBS Letters
Volume544
Issue number1-3
DOIs
Publication statusPublished - 2003 Jun 5

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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