Cancer initiation and progression are profoundly along with the crosstalk between cancer cells and the surrounding stroma. Accumulating evidence has shown that the therapy targeting the extracellular matrix (ECM) would regress tumor growth and invasion in the most common carcinomas. However, it remains largely unexplored in several rare tumors like odontogenic tumors. Ameloblastoma (AM) is the representative odontogenic epithelial tumor in the jawbone, and it usually infiltrates into adjacent bone marrow and has unlimited growth capacity and a high potential for recurrence. This study aims to investigate the role of collagen-rich ECM during the invasion of AM. Transcriptomic analysis revealed that ECM and epithelial-to-mesenchymal transition (EMT)-related genes were up-regulated in AM compared to ameloblastoma cell line, AM-1. Tumoroid forming analysis showed that Collagen-rich ECM is indispensable for AM progression, especially for aggressive growth patterns and collective invasion.
|Number of pages||7|
|Journal||International Journal of Stem Cells|
|Publication status||Published - 2022|
Bibliographical noteFunding Information:
This study was supported by the Yonsei University College of Dentistry Fund (6-2019-0014). The skillful assistance for visualizing RNA-seq data of Junsoo Song (NGeneS Inc.) is gratefully acknowledged.
This study was supported by the Yonsei University College of Dentistry Fund (6-2019-0014). The skillful assistance for visualizing RNA-seq data of Junsoo Song (NGeneS Inc.) is gratefully acknowledged
© 2022 by the Korean Society for Stem Cell Research
All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology