Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study

Hyeon Park, Donghee Park, Jongho Won, Jiyoung Jang, Bomi Hong, Yujin Park, Chulwoo Kim, Jongbum Seo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In previous studies, we have found that addition of cavitation seed such as ultrasound contrast agents (UCA) in sonophoresis accelerate and increase efficiency of transdermal drug delivery (TDD). Actively-induced cavitation with low intensity ultrasound (less than 1 MPa) on the skin causes disordering of the lipid bilayers and the formation of aqueous channels. However, commercial UCAs also have limit, because mixed UCA is uniformly positioned in the water based solution, not on the skin surface. In order to enhance the TDD, the cavitation effect of cavitation seed should be generated near skin surface. For that reason, we manufactured specialized cavitation seed for TDD, which can be sank near skin surface by gravity. In order to make sure possibility of macromolecules delivery using cavitation seed, we performed in vivo experiment using sonophoresis with specialized cavitation seed.

Original languageEnglish
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
Publication statusPublished - 2017 Oct 31
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 2017 Sep 62017 Sep 9

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period17/9/617/9/9

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All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Park, H., Park, D., Won, J., Jang, J., Hong, B., Park, Y., Kim, C., & Seo, J. (2017). Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 [8091882] (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8091882