Transdermal dihydrotestosterone therapy and its effects on patients with microphallus

S. K. Choi, Sangwon Han, D. H. Kim, B. De Lignieres, R. D. Walker, E. Kass, M. Mitchell, C. Flack, P. McKenna, C. Schulman, J. Duckett, D. Bloom, R. Decter, L. Baskin, H. Snyder, D. Poppas, M. D. Gibbons, M. Bellinger, K. Kropp

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Abstract

To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses of 12.5 mg. and 25 mg. for ages less than and older than 10 years, respectively. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. All patients demonstrated growth of the penis during treatment. The mean increase rate (153%) in the first 4 weeks of treatment was higher than that (118%) of the second 4 weeks. Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Serum alkaline phosphatase increased, mainly due to change of bone isoenzyme but bone ages and mean height velocity were not significantly affected. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalJournal of Urology
Volume150
Issue number2 SUPPL.
Publication statusPublished - 1993 Jan 1

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Dihydrotestosterone
Serum Globulins
Sex Hormone-Binding Globulin
Therapeutics
Lipid Metabolism
Bone and Bones
Genitalia
Penis
Growth
Isoenzymes
Alkaline Phosphatase
Testosterone
Gels
Serum

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Choi, S. K., Han, S., Kim, D. H., De Lignieres, B., Walker, R. D., Kass, E., ... Kropp, K. (1993). Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. Journal of Urology, 150(2 SUPPL.), 657-660.
Choi, S. K. ; Han, Sangwon ; Kim, D. H. ; De Lignieres, B. ; Walker, R. D. ; Kass, E. ; Mitchell, M. ; Flack, C. ; McKenna, P. ; Schulman, C. ; Duckett, J. ; Bloom, D. ; Decter, R. ; Baskin, L. ; Snyder, H. ; Poppas, D. ; Gibbons, M. D. ; Bellinger, M. ; Kropp, K. / Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. In: Journal of Urology. 1993 ; Vol. 150, No. 2 SUPPL. pp. 657-660.
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abstract = "To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses of 12.5 mg. and 25 mg. for ages less than and older than 10 years, respectively. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. All patients demonstrated growth of the penis during treatment. The mean increase rate (153{\%}) in the first 4 weeks of treatment was higher than that (118{\%}) of the second 4 weeks. Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Serum alkaline phosphatase increased, mainly due to change of bone isoenzyme but bone ages and mean height velocity were not significantly affected. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.",
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Choi, SK, Han, S, Kim, DH, De Lignieres, B, Walker, RD, Kass, E, Mitchell, M, Flack, C, McKenna, P, Schulman, C, Duckett, J, Bloom, D, Decter, R, Baskin, L, Snyder, H, Poppas, D, Gibbons, MD, Bellinger, M & Kropp, K 1993, 'Transdermal dihydrotestosterone therapy and its effects on patients with microphallus', Journal of Urology, vol. 150, no. 2 SUPPL., pp. 657-660.

Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. / Choi, S. K.; Han, Sangwon; Kim, D. H.; De Lignieres, B.; Walker, R. D.; Kass, E.; Mitchell, M.; Flack, C.; McKenna, P.; Schulman, C.; Duckett, J.; Bloom, D.; Decter, R.; Baskin, L.; Snyder, H.; Poppas, D.; Gibbons, M. D.; Bellinger, M.; Kropp, K.

In: Journal of Urology, Vol. 150, No. 2 SUPPL., 01.01.1993, p. 657-660.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transdermal dihydrotestosterone therapy and its effects on patients with microphallus

AU - Choi, S. K.

AU - Han, Sangwon

AU - Kim, D. H.

AU - De Lignieres, B.

AU - Walker, R. D.

AU - Kass, E.

AU - Mitchell, M.

AU - Flack, C.

AU - McKenna, P.

AU - Schulman, C.

AU - Duckett, J.

AU - Bloom, D.

AU - Decter, R.

AU - Baskin, L.

AU - Snyder, H.

AU - Poppas, D.

AU - Gibbons, M. D.

AU - Bellinger, M.

AU - Kropp, K.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses of 12.5 mg. and 25 mg. for ages less than and older than 10 years, respectively. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. All patients demonstrated growth of the penis during treatment. The mean increase rate (153%) in the first 4 weeks of treatment was higher than that (118%) of the second 4 weeks. Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Serum alkaline phosphatase increased, mainly due to change of bone isoenzyme but bone ages and mean height velocity were not significantly affected. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.

AB - To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses of 12.5 mg. and 25 mg. for ages less than and older than 10 years, respectively. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. All patients demonstrated growth of the penis during treatment. The mean increase rate (153%) in the first 4 weeks of treatment was higher than that (118%) of the second 4 weeks. Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Serum alkaline phosphatase increased, mainly due to change of bone isoenzyme but bone ages and mean height velocity were not significantly affected. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.

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Choi SK, Han S, Kim DH, De Lignieres B, Walker RD, Kass E et al. Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. Journal of Urology. 1993 Jan 1;150(2 SUPPL.):657-660.