Transdermal drug delivery using a specialized cavitation seed for ultrasound

Donghee Park, Jongho Won, Unchul Shin, Hyeon Park, Gillsoo Song, Jiyoung Jang, Hyunjin Park, Chul Woo Kim, Jong Bum Seo

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The sonophoresis, which utilizes ultrasound for transdermal drug delivery (TDD), can improve the efficiency of drug delivery for a variety of drugs predominantly due to cavitation effect. In order to increase the efficacy of sonophoresis, we propose an alternative cavitation seed specialized for sonophoresis, which can be concentrated on the skin surface by gravity adapting perfluorohexane as core. Methods: In vitro and in vivo experiments were conducted to assess the effect of the specialized cavitation seed. High-performance liquid chromatography (HPLC) was used for in vitro experiments on porcine skin with ferulic acid, and an optical imaging system was used for in vivo experiments on the rat model with fluorescein isothiocyanate-dextran (FD, 150 kDa), respectively. Results: The amount of ferulic acid delivered by sonophoresis with the proposed cavitation seed was approximately 1700 times greater than the amount delivered by diffusion. FD could be delivered to a depth of $500~\mu \text{m}$ under the skin, and the average total flux in the region of interest was increased 6.4-fold for the group using sonophoresis with the cavitation seed compared to the group using diffusion. Conclusion: Conclusively, sonophoresis with the proposed cavitation seed demonstrated the significant improvement in TDD and the possibility of macromolecule delivery into the skin. Significance: This approach has potential to be a main TDD method for variety of applications including medicine and cosmetics.

Original languageEnglish
Article number8678715
Pages (from-to)1057-1064
Number of pages8
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume66
Issue number6
DOIs
Publication statusPublished - 2019 Jun

Bibliographical note

Funding Information:
Manuscript received September 28, 2018; accepted March 15, 2019. Date of publication April 1, 2019; date of current version June 5, 2019. This work was supported by the Convergent Technology Development Business Research and Development Program funded by the Small and Medium Business Administration (SMBA, South Korea) in 2016 under Grant S2449015. (Corresponding author: Jongbum Seo.) D. Park, J. Won, H. Park, J. Jang, and C.-W. Kim are with BioInfra Life Science Inc., Seoul 03127, South Korea.

Publisher Copyright:
© 2019 IEEE.

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

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