Abstract
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-B). We investigated the association of non-small cell lung cancer (NSCLC) treatment efficacy with TG2 and NF-B expression in 120 patients: 102 with adenocarcinoma and 18 with other histologic types. All patients underwent surgery; 88 received adjuvant chemotherapy, with 28 receiving platinum-based doublet chemotherapy as first-line treatment and 29 receiving epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy. Patients' TG2 and NF-B expression values were calculated semiquantitatively. The median TG2 value was 50 (range, 0-300) and the median NF-B value was 20 (range, 0-240). Disease-free survival did not differ between the low- and high-TG2 groups. Among patients who received palliative platinumbased doublet chemotherapy, progression free survival (PFS) was longer in the low-TG2 group than in the high-TG2 group (11.0 vs. 7.0 months; P = 0.330). Among those who received EGFR-TKI therapy, PFS was also longer in the low-TG2 group than in the high-TG 2 group (11.0 vs. 2.0 months; P = 0.013). Similarly, in EGFR wild-type patients treatedwith EGFR-TKI, PFS was longer in patients with low TG2 expression (9.0 vs. 2.0 months; P = 0.013). TG2 expression levels can predict PFS in patients with NSCLC treated with EGFR-TKI
Original language | English |
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Pages (from-to) | 1005-1014 |
Number of pages | 10 |
Journal | Journal of Korean medical science |
Volume | 28 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2013 Jul |
All Science Journal Classification (ASJC) codes
- Medicine(all)