Transient expression of phospholipase D1 during heart development in rats

Changjong Moon, Heechul Kim, Seungjoon Kim, Yongduk Lee, Min Kyoung Shin, Do Sik Min, Taekyun Shin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The expression of phospholipase D (PLD) isozymes was examined in the hearts of rats at different stages of development. Immunoprecipitation and Western blot analysis revealed weak PLD1 expression in the hearts of day 17 embryos. The level of PLD1 protein increased transiently 0 and 3 days postpartum, and declined gradually beginning 7 days after birth. Immunohistochemistry revealed weak PLD1 immunostaining in some cells at embryonic day 17. In contrast, some vascular endothelial cells and cardiomyocytes were immunostained typically at days 0, 3, and 7 after birth. After postnatal day 21, weak PLD1 expression was immunodetected in some vascular endothelial cells and cardiomyocytes. This suggests that the PLD1 protein in the heart is strongly associated with the early postnatal development of the heart in rats.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalJournal of Veterinary Medical Science
Volume70
Issue number4
DOIs
Publication statusPublished - 2008 Apr

All Science Journal Classification (ASJC) codes

  • veterinary(all)

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