Transient new-onset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction

Jin Wi, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Myeong Ki Hong, Yangsoo Jang

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Background: Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes. Methods and Results: Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004). Conclusions: Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients.

Original languageEnglish
Pages (from-to)1615-1623
Number of pages9
JournalCirculation Journal
Issue number7
Publication statusPublished - 2016 Jan 1


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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