Transient new-onset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction

Jin Wi, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Myeongki Hong, Yangsoo Jang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes. Methods and Results: Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004). Conclusions: Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients.

Original languageEnglish
Pages (from-to)1615-1623
Number of pages9
JournalCirculation Journal
Volume80
Issue number7
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Atrial Fibrillation
Myocardial Infarction
Confidence Intervals
Cause of Death
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{27c5798fcb994a84a04eb2b14e162c44,
title = "Transient new-onset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction",
abstract = "Background: Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes. Methods and Results: Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9{\%}) and transient NOAF occurred in 102 (4.8{\%}) among 150 patients (7.1{\%}) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0{\%}, P<0.001), 2-year (37.8 vs. 20.7{\%}, P<0.001), and 5-year MACE rates (51.8 vs. 28.0{\%}, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2{\%}, P<0.001), 1-month (17.9 vs. 5.7{\%}, P<0.001), 2-year (30.0 vs. 11.6{\%}, P<0.001), and 5-year mortality rates (36.9 vs. 14.0{\%}, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95{\%} confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95{\%} CI 1.22–2.85, P=0.004). Conclusions: Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients.",
author = "Jin Wi and Shin, {Dong Ho} and Kim, {Jung Sun} and Kim, {Byeong Keuk} and Ko, {Young Guk} and Donghoon Choi and Myeongki Hong and Yangsoo Jang",
year = "2016",
month = "1",
day = "1",
doi = "10.1253/circj.CJ-15-1250",
language = "English",
volume = "80",
pages = "1615--1623",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "7",

}

Transient new-onset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction. / Wi, Jin; Shin, Dong Ho; Kim, Jung Sun; Kim, Byeong Keuk; Ko, Young Guk; Choi, Donghoon; Hong, Myeongki; Jang, Yangsoo.

In: Circulation Journal, Vol. 80, No. 7, 01.01.2016, p. 1615-1623.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transient new-onset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction

AU - Wi, Jin

AU - Shin, Dong Ho

AU - Kim, Jung Sun

AU - Kim, Byeong Keuk

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Hong, Myeongki

AU - Jang, Yangsoo

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes. Methods and Results: Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004). Conclusions: Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients.

AB - Background: Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes. Methods and Results: Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004). Conclusions: Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients.

UR - http://www.scopus.com/inward/record.url?scp=84975767461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975767461&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-15-1250

DO - 10.1253/circj.CJ-15-1250

M3 - Article

C2 - 27210266

AN - SCOPUS:84975767461

VL - 80

SP - 1615

EP - 1623

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 7

ER -