Abstract
Panhypogammaglobulinaemia is a rare complication of systemic lupus erythematosus (SLE), but its cause and mechanism are unclear. We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide. After the patient developed recurrent infections, laboratory findings disclosed panhypogammaglobulinaemia with B-lymphocyte deficiency. The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off. Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency. However, this reversible, probably drug-induced case of hypogammaglobulinaemia high-lights the need for immunoglobulin measurements when immunodeficiency is suspected in lupus patients.
| Original language | English |
|---|---|
| Pages (from-to) | 62-66 |
| Number of pages | 5 |
| Journal | Clinical Rheumatology |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Rheumatology
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Transient panhypogammaglobulinaemia and B-lymphocyte deficiency in a patient with neuropsychiatric systemic lupus erythematosus after immunosuppressive therapy. / Song, J.; Park, YongBeom; Suh, C. H.; Lee, S. K.
In: Clinical Rheumatology, Vol. 22, No. 1, 01.02.2003, p. 62-66.Research output: Contribution to journal › Article
TY - JOUR
T1 - Transient panhypogammaglobulinaemia and B-lymphocyte deficiency in a patient with neuropsychiatric systemic lupus erythematosus after immunosuppressive therapy
AU - Song, J.
AU - Park, YongBeom
AU - Suh, C. H.
AU - Lee, S. K.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Panhypogammaglobulinaemia is a rare complication of systemic lupus erythematosus (SLE), but its cause and mechanism are unclear. We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide. After the patient developed recurrent infections, laboratory findings disclosed panhypogammaglobulinaemia with B-lymphocyte deficiency. The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off. Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency. However, this reversible, probably drug-induced case of hypogammaglobulinaemia high-lights the need for immunoglobulin measurements when immunodeficiency is suspected in lupus patients.
AB - Panhypogammaglobulinaemia is a rare complication of systemic lupus erythematosus (SLE), but its cause and mechanism are unclear. We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide. After the patient developed recurrent infections, laboratory findings disclosed panhypogammaglobulinaemia with B-lymphocyte deficiency. The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off. Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency. However, this reversible, probably drug-induced case of hypogammaglobulinaemia high-lights the need for immunoglobulin measurements when immunodeficiency is suspected in lupus patients.
UR - http://www.scopus.com/inward/record.url?scp=0038543279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038543279&partnerID=8YFLogxK
U2 - 10.1007/s10067-002-0655-4
DO - 10.1007/s10067-002-0655-4
M3 - Article
C2 - 12605322
AN - SCOPUS:0038543279
VL - 22
SP - 62
EP - 66
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 1
ER -