Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

Jung Kyu Choi; Gevorg Sargsyan; Breiana D. Johnson; Milan Balaz

doi:10.1039/c4ra16453a

Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

Jung Kyu Choi, Gevorg Sargsyan, Breiana D. Johnson, Milan Balaz

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M²⁺) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M²⁺ = Hg²⁺ or Cu²⁺) allow the switching of the emission and absorption response of the ZnPorT8/M²⁺ complex. The ZnPorT8/Hg²⁺ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu²⁺ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg²⁺ and ZnPorT8/Cu²⁺ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively).

Original language	English
Pages (from-to)	15916-15922
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	21
DOIs	https://doi.org/10.1039/c4ra16453a
Publication status	Published - 2015

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Publisher Copyright:
© 2015 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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title = "Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives",

abstract = "We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively).",

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AU - Choi, Jung Kyu

AU - Sargsyan, Gevorg

AU - Johnson, Breiana D.

AU - Balaz, Milan

PY - 2015

Y1 - 2015

N2 - We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively).

AB - We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively).

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Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

Abstract

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