Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

Jung Kyu Choi, Gevorg Sargsyan, Breiana D. Johnson, Milan Balaz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively). This journal is

Original languageEnglish
Pages (from-to)15916-15922
Number of pages7
JournalRSC Advances
Volume5
Issue number21
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Porphyrins
Transition metals
Metal ions
Cysteine
DNA
Fluorescence
Switches
Derivatives
Quenching
Zinc
Glutathione

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Choi, Jung Kyu ; Sargsyan, Gevorg ; Johnson, Breiana D. ; Balaz, Milan. / Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives. In: RSC Advances. 2015 ; Vol. 5, No. 21. pp. 15916-15922.
@article{4515e0b2d52f468095fb36791f61070d,
title = "Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives",
abstract = "We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively). This journal is",
author = "Choi, {Jung Kyu} and Gevorg Sargsyan and Johnson, {Breiana D.} and Milan Balaz",
year = "2015",
month = "1",
day = "1",
doi = "10.1039/c4ra16453a",
language = "English",
volume = "5",
pages = "15916--15922",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "21",

}

Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives. / Choi, Jung Kyu; Sargsyan, Gevorg; Johnson, Breiana D.; Balaz, Milan.

In: RSC Advances, Vol. 5, No. 21, 01.01.2015, p. 15916-15922.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

AU - Choi, Jung Kyu

AU - Sargsyan, Gevorg

AU - Johnson, Breiana D.

AU - Balaz, Milan

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively). This journal is

AB - We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively). This journal is

UR - http://www.scopus.com/inward/record.url?scp=84922779079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922779079&partnerID=8YFLogxK

U2 - 10.1039/c4ra16453a

DO - 10.1039/c4ra16453a

M3 - Article

VL - 5

SP - 15916

EP - 15922

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 21

ER -