Transplant graft vasculopathy: An emerging target for prevention and treatment of renal allograft dysfunction

Duk Hee Kang, Shin Wook Kang, Hyeon Joo Jeong, Yu Seun Kim, Chul Woo Yang, Richard J. Johnson

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Maintenance of healthy endothelium is essential to vascular homeostasis, and preservation of endothelial cell function is critical for transplant allograft function. Damage of microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection and chronic allograft nephropathy, which is an important predictor of graft loss and is often associated with transplant vasculopathy. In this review, we will discuss the role of microvascular endothelium, in renal allograft dysfunction, particularly as it relates to markers of endothelial dysfunction and endothelial repair mechanisms. We also discuss the potential for therapies targeting endothelial dysfunction and transplant graft vasculopathy.

Original languageEnglish
Pages (from-to)1053-1058
Number of pages6
JournalYonsei medical journal
Volume45
Issue number6
DOIs
Publication statusPublished - 2004 Dec 31

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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