Transplantation of an adipose stem cell cluster in a spinal cord injury

Jin Soo Oh, In Su Park, Keung Nyun Kim, Do Heum Yoon, Sang Heon Kim, Yoon Ha

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27 Citations (Scopus)

Abstract

We investigated whether transplantation of a threedimensional cell mass of adipose-derived stem cells (3DCM-ASCs) improved hind limb functional recovery by the stimulation of angiogenesis and neurogenesis in a spinal cord injury. In in-vitro experiments, we confirmed that 3DCM-ASCs differentiated into CD31-positive endothelial cells. To evaluate the therapeutic effect of 3DCM-ASCs in vivo, PBS, human adipose tissue-derived stem cells, and 3DCM-ASCs were transplanted into a spinal cord injury model. The 3DCM-ASCs transplanted into the injured spinal cord differentiated into CD31-positive endothelial cells and remained differentiated. Transplantation of 3DCM-ASCs into the injured spinal cord significantly elevated the density of vascular formations through angiogenic factors released by the 3DCM-ASCs at the lesion site, and enhanced axonal outgrowth at the lesion site. Consistent with these results, the transplantation of 3DCM-ASCs significantly improved functional recovery compared with both ASC transplantation and PBS treatment. These findings suggest that transplantation of 3DCM-ASCs may be an effective stem cell therapy for the treatment of spinal cord injuries and neural ischemia.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalNeuroReport
Volume23
Issue number5
DOIs
Publication statusPublished - 2012 Mar 28

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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