Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration

Byung Ho Choi; S. J. Zhu; B. Y. Kim; J. Y. Huh; S. H. Lee; J. H. Jung

doi:10.1016/j.ijom.2004.10.017

Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration

Byung Ho Choi, S. J. Zhu, B. Y. Kim, J. Y. Huh, S. H. Lee, J. H. Jung

Dentistry

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 10⁶), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

Original language	English
Pages (from-to)	537-542
Number of pages	6
Journal	International journal of oral and maxillofacial surgery
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.ijom.2004.10.017
Publication status	Published - 2005 Jul

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology

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title = "Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration",

abstract = "The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.",

author = "Choi, {Byung Ho} and Zhu, {S. J.} and Kim, {B. Y.} and Huh, {J. Y.} and Lee, {S. H.} and Jung, {J. H.}",

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AU - Choi, Byung Ho

AU - Zhu, S. J.

AU - Kim, B. Y.

AU - Huh, J. Y.

AU - Lee, S. H.

AU - Jung, J. H.

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AB - The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

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