Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration

Byung Ho Choi, S. J. Zhu, B. Y. Kim, J. Y. Huh, S. H. Lee, J. H. Jung

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

Original languageEnglish
Pages (from-to)537-542
Number of pages6
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume34
Issue number5
DOIs
Publication statusPublished - 2005 Jul 1

Fingerprint

Nerve Regeneration
Mesenchymal Stromal Cells
Peripheral Nerves
Cultured Cells
Transplantation
Peroneal Nerve
Veins
Collagen
Gels
Rabbits

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Choi, Byung Ho ; Zhu, S. J. ; Kim, B. Y. ; Huh, J. Y. ; Lee, S. H. ; Jung, J. H. / Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration. In: International Journal of Oral and Maxillofacial Surgery. 2005 ; Vol. 34, No. 5. pp. 537-542.
@article{2b91b1aba464460d9b84fff5350ac878,
title = "Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration",
abstract = "The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.",
author = "Choi, {Byung Ho} and Zhu, {S. J.} and Kim, {B. Y.} and Huh, {J. Y.} and Lee, {S. H.} and Jung, {J. H.}",
year = "2005",
month = "7",
day = "1",
doi = "10.1016/j.ijom.2004.10.017",
language = "English",
volume = "34",
pages = "537--542",
journal = "International Journal of Oral and Maxillofacial Surgery",
issn = "0901-5027",
publisher = "Churchill Livingstone",
number = "5",

}

Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration. / Choi, Byung Ho; Zhu, S. J.; Kim, B. Y.; Huh, J. Y.; Lee, S. H.; Jung, J. H.

In: International Journal of Oral and Maxillofacial Surgery, Vol. 34, No. 5, 01.07.2005, p. 537-542.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration

AU - Choi, Byung Ho

AU - Zhu, S. J.

AU - Kim, B. Y.

AU - Huh, J. Y.

AU - Lee, S. H.

AU - Jung, J. H.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

AB - The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

UR - http://www.scopus.com/inward/record.url?scp=20344401050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344401050&partnerID=8YFLogxK

U2 - 10.1016/j.ijom.2004.10.017

DO - 10.1016/j.ijom.2004.10.017

M3 - Article

VL - 34

SP - 537

EP - 542

JO - International Journal of Oral and Maxillofacial Surgery

JF - International Journal of Oral and Maxillofacial Surgery

SN - 0901-5027

IS - 5

ER -