Abstract
The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 537-542 |
| Number of pages | 6 |
| Journal | International Journal of Oral and Maxillofacial Surgery |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology
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Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration. / Choi, Byung Ho; Zhu, S. J.; Kim, B. Y.; Huh, J. Y.; Lee, S. H.; Jung, J. H.
In: International Journal of Oral and Maxillofacial Surgery, Vol. 34, No. 5, 01.07.2005, p. 537-542.Research output: Contribution to journal › Article
TY - JOUR
T1 - Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration
AU - Choi, Byung Ho
AU - Zhu, S. J.
AU - Kim, B. Y.
AU - Huh, J. Y.
AU - Lee, S. H.
AU - Jung, J. H.
PY - 2005/7/1
Y1 - 2005/7/1
N2 - The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.
AB - The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 × 106), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.
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UR - http://www.scopus.com/inward/citedby.url?scp=20344401050&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2004.10.017
DO - 10.1016/j.ijom.2004.10.017
M3 - Article
VL - 34
SP - 537
EP - 542
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
SN - 0901-5027
IS - 5
ER -