Transport disc distraction osteogenesis for the reconstruction of a calvarial defect

In Sik Yun, Hye Young Mun, Jong Won Hong, Eul Je Cho, Dae Gon Woo, Han Sung Kim, Yong Oock Kim, Be Young Yun Park, Dong Kyun Rah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE:: According to previous reports about the experimental study of transport disk distraction osteogenesis (TDDO) for the reconstruction of bone defects, TDDO showed great feasibility of successful bone regeneration. However, those studies had some limitations in their design and analysis of the results, either. In this report, we intended to verify the effect of TDDO in the reconstruction of skull defects with a combined result of distraction osteogenesis and bone graft of transported disk (TD). METHODS:: Six female dogs were operated on and were given a 35 x 15-mm bilateral skull defect. In the experimental group, TDDO with internal distractors (7 x 14-mm TD) was performed. On the other side, in the control group, the bone defects were left to heal naturally. The distraction was performed from the postoperative fifth day at a rate of 1 mm/d. The distraction progressed for 14 days, and then the TD was maintained in the middle of the bone defect area. The 40% of the original bone defect area was left the same as the control side. The TD was expected to be survived as a bone graft during the consolidation period. After 31/2 months of a consolidation period, the remained bone defects were measured by three-dimensional computed tomography. The solidity of the new bone was compared with the bone tissue of the normal skull bone. RESULTS:: In the study group, the new bone formation was estimated to be 62.3% (SD, 25.1%) of the defect area, and in the control group, it was 44.8% (SD, 27.3%). The difference between the 2 groups was significant (P = 0.04). The solidity of the newly generated bone by TDDO was not different from the normal skull (P = 0.74). CONCLUSIONS:: In this study, the concept of TDDO and bone graft seemed to promote new bone formation. The role of the TD could include bone regeneration from distraction osteogenesis as well as autogenous bone graft, although it needs more investigation. The relationship between the duration of distraction and the positive role of the TD as an autogenous bone graft in TDDO for better clinical application may be investigated.

Original languageEnglish
Pages (from-to)690-693
Number of pages4
JournalJournal of Craniofacial Surgery
Volume22
Issue number2
DOIs
Publication statusPublished - 2011 Mar 1

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Distraction Osteogenesis
Bone and Bones
Skull
Transplants
Bone Regeneration
Osteogenesis
Control Groups

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Yun, In Sik ; Mun, Hye Young ; Hong, Jong Won ; Cho, Eul Je ; Woo, Dae Gon ; Kim, Han Sung ; Kim, Yong Oock ; Park, Be Young Yun ; Rah, Dong Kyun. / Transport disc distraction osteogenesis for the reconstruction of a calvarial defect. In: Journal of Craniofacial Surgery. 2011 ; Vol. 22, No. 2. pp. 690-693.
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abstract = "PURPOSE:: According to previous reports about the experimental study of transport disk distraction osteogenesis (TDDO) for the reconstruction of bone defects, TDDO showed great feasibility of successful bone regeneration. However, those studies had some limitations in their design and analysis of the results, either. In this report, we intended to verify the effect of TDDO in the reconstruction of skull defects with a combined result of distraction osteogenesis and bone graft of transported disk (TD). METHODS:: Six female dogs were operated on and were given a 35 x 15-mm bilateral skull defect. In the experimental group, TDDO with internal distractors (7 x 14-mm TD) was performed. On the other side, in the control group, the bone defects were left to heal naturally. The distraction was performed from the postoperative fifth day at a rate of 1 mm/d. The distraction progressed for 14 days, and then the TD was maintained in the middle of the bone defect area. The 40{\%} of the original bone defect area was left the same as the control side. The TD was expected to be survived as a bone graft during the consolidation period. After 31/2 months of a consolidation period, the remained bone defects were measured by three-dimensional computed tomography. The solidity of the new bone was compared with the bone tissue of the normal skull bone. RESULTS:: In the study group, the new bone formation was estimated to be 62.3{\%} (SD, 25.1{\%}) of the defect area, and in the control group, it was 44.8{\%} (SD, 27.3{\%}). The difference between the 2 groups was significant (P = 0.04). The solidity of the newly generated bone by TDDO was not different from the normal skull (P = 0.74). CONCLUSIONS:: In this study, the concept of TDDO and bone graft seemed to promote new bone formation. The role of the TD could include bone regeneration from distraction osteogenesis as well as autogenous bone graft, although it needs more investigation. The relationship between the duration of distraction and the positive role of the TD as an autogenous bone graft in TDDO for better clinical application may be investigated.",
author = "Yun, {In Sik} and Mun, {Hye Young} and Hong, {Jong Won} and Cho, {Eul Je} and Woo, {Dae Gon} and Kim, {Han Sung} and Kim, {Yong Oock} and Park, {Be Young Yun} and Rah, {Dong Kyun}",
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Yun, IS, Mun, HY, Hong, JW, Cho, EJ, Woo, DG, Kim, HS, Kim, YO, Park, BYY & Rah, DK 2011, 'Transport disc distraction osteogenesis for the reconstruction of a calvarial defect', Journal of Craniofacial Surgery, vol. 22, no. 2, pp. 690-693. https://doi.org/10.1097/SCS.0b013e31820779b7

Transport disc distraction osteogenesis for the reconstruction of a calvarial defect. / Yun, In Sik; Mun, Hye Young; Hong, Jong Won; Cho, Eul Je; Woo, Dae Gon; Kim, Han Sung; Kim, Yong Oock; Park, Be Young Yun; Rah, Dong Kyun.

In: Journal of Craniofacial Surgery, Vol. 22, No. 2, 01.03.2011, p. 690-693.

Research output: Contribution to journalArticle

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T1 - Transport disc distraction osteogenesis for the reconstruction of a calvarial defect

AU - Yun, In Sik

AU - Mun, Hye Young

AU - Hong, Jong Won

AU - Cho, Eul Je

AU - Woo, Dae Gon

AU - Kim, Han Sung

AU - Kim, Yong Oock

AU - Park, Be Young Yun

AU - Rah, Dong Kyun

PY - 2011/3/1

Y1 - 2011/3/1

N2 - PURPOSE:: According to previous reports about the experimental study of transport disk distraction osteogenesis (TDDO) for the reconstruction of bone defects, TDDO showed great feasibility of successful bone regeneration. However, those studies had some limitations in their design and analysis of the results, either. In this report, we intended to verify the effect of TDDO in the reconstruction of skull defects with a combined result of distraction osteogenesis and bone graft of transported disk (TD). METHODS:: Six female dogs were operated on and were given a 35 x 15-mm bilateral skull defect. In the experimental group, TDDO with internal distractors (7 x 14-mm TD) was performed. On the other side, in the control group, the bone defects were left to heal naturally. The distraction was performed from the postoperative fifth day at a rate of 1 mm/d. The distraction progressed for 14 days, and then the TD was maintained in the middle of the bone defect area. The 40% of the original bone defect area was left the same as the control side. The TD was expected to be survived as a bone graft during the consolidation period. After 31/2 months of a consolidation period, the remained bone defects were measured by three-dimensional computed tomography. The solidity of the new bone was compared with the bone tissue of the normal skull bone. RESULTS:: In the study group, the new bone formation was estimated to be 62.3% (SD, 25.1%) of the defect area, and in the control group, it was 44.8% (SD, 27.3%). The difference between the 2 groups was significant (P = 0.04). The solidity of the newly generated bone by TDDO was not different from the normal skull (P = 0.74). CONCLUSIONS:: In this study, the concept of TDDO and bone graft seemed to promote new bone formation. The role of the TD could include bone regeneration from distraction osteogenesis as well as autogenous bone graft, although it needs more investigation. The relationship between the duration of distraction and the positive role of the TD as an autogenous bone graft in TDDO for better clinical application may be investigated.

AB - PURPOSE:: According to previous reports about the experimental study of transport disk distraction osteogenesis (TDDO) for the reconstruction of bone defects, TDDO showed great feasibility of successful bone regeneration. However, those studies had some limitations in their design and analysis of the results, either. In this report, we intended to verify the effect of TDDO in the reconstruction of skull defects with a combined result of distraction osteogenesis and bone graft of transported disk (TD). METHODS:: Six female dogs were operated on and were given a 35 x 15-mm bilateral skull defect. In the experimental group, TDDO with internal distractors (7 x 14-mm TD) was performed. On the other side, in the control group, the bone defects were left to heal naturally. The distraction was performed from the postoperative fifth day at a rate of 1 mm/d. The distraction progressed for 14 days, and then the TD was maintained in the middle of the bone defect area. The 40% of the original bone defect area was left the same as the control side. The TD was expected to be survived as a bone graft during the consolidation period. After 31/2 months of a consolidation period, the remained bone defects were measured by three-dimensional computed tomography. The solidity of the new bone was compared with the bone tissue of the normal skull bone. RESULTS:: In the study group, the new bone formation was estimated to be 62.3% (SD, 25.1%) of the defect area, and in the control group, it was 44.8% (SD, 27.3%). The difference between the 2 groups was significant (P = 0.04). The solidity of the newly generated bone by TDDO was not different from the normal skull (P = 0.74). CONCLUSIONS:: In this study, the concept of TDDO and bone graft seemed to promote new bone formation. The role of the TD could include bone regeneration from distraction osteogenesis as well as autogenous bone graft, although it needs more investigation. The relationship between the duration of distraction and the positive role of the TD as an autogenous bone graft in TDDO for better clinical application may be investigated.

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