Treatment of osteofibrous dysplasia and associated lesions

Soo Boug Hahn, Sung Hun Kim, Nam Hoon Cho, Chul Jun Choi, Bom Soo Kim, Ho Jung Kang

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Abstract

Purpose: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma. Patients and Methods: From January 1984 to July 2001, 14 patients with osteofibrous dysplasia were followed for an average of 108 months (78 to 260 months). Our patient group consisted of 6 men and 8 women, with a mean age of 13.9 years (2 to 65 years). We reviewed the clinical and pathological features of all 14 patients. Results: Thirteen patients bad a lesion in the tibia, while one patient had lesions in both the tibia and the fibula. Initial treatments were observation after biopsy (6 patients), curettage with or without a bone graft (3 patients), resection followed by a free vascularized fibular bone graft (4 patients), or resection and regeneration with the Ilizarov external fixauon (1 patient). Curettage was performed on 6 patients due to recurrence or progression after the initial treatment. Among these patients, one was diagnosed with AD from the biopsy of the recurrent lesion. This patient was further treated by segmental resection and pasteurization. After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma. Conclusion: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.

Original languageEnglish
Pages (from-to)502-510
Number of pages9
JournalYonsei medical journal
Volume48
Issue number3
DOIs
Publication statusPublished - 2007 Jun 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hahn, S. B., Kim, S. H., Cho, N. H., Choi, C. J., Kim, B. S., & Kang, H. J. (2007). Treatment of osteofibrous dysplasia and associated lesions. Yonsei medical journal, 48(3), 502-510. https://doi.org/10.3349/ymj.2007.48.3.502