Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: A multicenter retrospective study

Yunsuk Choi, Jung Hee Lee, Chul Won Jung, Jae Cheol Jo, Jin Seok Kim, Inho Kim, Silvia Park, June Won Cheong, Sang Hyuk Park, Sung Yong Kim, Hong Ghi Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background/Aims: Compared with Western countries, chronic lymphocytic leukemia (CLL) rarely occurs in Asia and has different clinical characteristics. Thus, we aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic significance of Korean patients with CLL. Methods: We retrospectively analyzed 90 patients with CLL who had received chemotherapy at 6 centers in Korea between 2000 and 2012. Results: Compared with Western patients with CLL, Korean patients with CLL express lambda (42.0%) and atypical markers such as CD22 and FMC7 (76.7% and 40.0%, respectively) more frequently. First-line chemotherapy regimens included chlorambucil (n = 43), fludarabine and cyclophosphamide (FC) (n = 20), fludarabine (n = 13), rituximab-FC (n = 4). The remaining patients were treated with other various regimens (n = 10). The 5-year overall survival (OS) and progression-free survival (PFS) rates were 79.3% and 28.1%, respectively. Multivariate analyses showed that hyper-leukocytosis (≥ 100 × 103/μL), extranodal involvement, and the Binet C stage were sig-nificant negative prognostic factors for OS (hazard ratio [HR] 4.75, p = 0.039; HR 21.6, p = 0.002; and HR 4.35, p = 0.034, respectively). Cytogenetic abnormalities including complex karyotypes (≥ 3), del(11q), and del(17) had a significantly adverse impact on both OS and PFS (p < 0.001 and p = 0.010, respectively). Conclusions: Initial hyperleukocytosis, extranodal involvement, complex karyotype, del(17) and del(11q) need to be considered in the risk stratification system for CLL.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalKorean Journal of Internal Medicine
Issue number1
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (NRF-2017R1C1B5015107) (to Yunsuk Choi).

Publisher Copyright:
© 2021 The Korean Association of Internal Medicine.

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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