Treatment outcomes of curative radiotherapy in patients with vulvar cancer

Results of the retrospective KROG 1203 study

Youngkyong Kim, Joo Young Kim, Ja Young Kim, Nam Kwon Lee, Jin Hee Kim, Yongbae Kim, Young Seok Kim, Juree Kim, Yeon Sil Kim, Dae Sik Yang, Yeon Joo Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy. Materials and Methods: Overall survival (OS) and disease-free survival (DFS) were assessed retrospectively. Prognostic factors evaluated included age, International Federation of Gynecology and Obstetrics (FIGO) stage, TNM classification, tumor size, treatment modality, RT duration, and RT field. The association between the tumor human papillomavirus (HPV) status and survival was analyzed in 35 patients. Results: During the median follow-up of 2.8 years (range, 0.3 to 18.9 years), 21 patients (37.5%) experienced treatment failure. Fifteen patients (27%) had local failure: nine (16%) local failure only, three (5%) locoregional failure, two (4%) local and distant failure, and one (2%) locoregional and distant failure. Of 56 patients, seven (13%) had persistent disease at the first follow-up at 2 months and all but one died within a year after completing RT. The 5-year OS and DFS were 51.6% and 44.0%, respectively. In multivariate analysis, clinical size ≥3 cm predicted a poor prognostic factor for DFS (p = 0.040) and age (≥70 years) was poor prognostic for DFS (p = 0.032) and OS (p = 0.048). Patients with HPV-positive tumors tended to have better 5-year OS and DFS, but the differences were not significant statistically. Conclusion: Clinical size ≥3 cm was a significant prognostic factor for DFS. However, age was the most important prognostic factor for DFS and OS in patients treated with curative RT. Further studies are needed to determine which treatment should be considered for old age ≥70 years.

Original languageEnglish
Pages (from-to)198-206
Number of pages9
JournalRadiation Oncology Journal
Volume33
Issue number3
DOIs
Publication statusPublished - 2015 Sep 1

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Vulvar Neoplasms
Disease-Free Survival
Radiotherapy
Survival
Neoplasms
Neoplasm Staging
Chemoradiotherapy
Treatment Failure
Gynecology
Obstetrics
Multivariate Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Youngkyong ; Kim, Joo Young ; Kim, Ja Young ; Lee, Nam Kwon ; Kim, Jin Hee ; Kim, Yongbae ; Kim, Young Seok ; Kim, Juree ; Kim, Yeon Sil ; Yang, Dae Sik ; Kim, Yeon Joo. / Treatment outcomes of curative radiotherapy in patients with vulvar cancer : Results of the retrospective KROG 1203 study. In: Radiation Oncology Journal. 2015 ; Vol. 33, No. 3. pp. 198-206.
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title = "Treatment outcomes of curative radiotherapy in patients with vulvar cancer: Results of the retrospective KROG 1203 study",
abstract = "Purpose: We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy. Materials and Methods: Overall survival (OS) and disease-free survival (DFS) were assessed retrospectively. Prognostic factors evaluated included age, International Federation of Gynecology and Obstetrics (FIGO) stage, TNM classification, tumor size, treatment modality, RT duration, and RT field. The association between the tumor human papillomavirus (HPV) status and survival was analyzed in 35 patients. Results: During the median follow-up of 2.8 years (range, 0.3 to 18.9 years), 21 patients (37.5{\%}) experienced treatment failure. Fifteen patients (27{\%}) had local failure: nine (16{\%}) local failure only, three (5{\%}) locoregional failure, two (4{\%}) local and distant failure, and one (2{\%}) locoregional and distant failure. Of 56 patients, seven (13{\%}) had persistent disease at the first follow-up at 2 months and all but one died within a year after completing RT. The 5-year OS and DFS were 51.6{\%} and 44.0{\%}, respectively. In multivariate analysis, clinical size ≥3 cm predicted a poor prognostic factor for DFS (p = 0.040) and age (≥70 years) was poor prognostic for DFS (p = 0.032) and OS (p = 0.048). Patients with HPV-positive tumors tended to have better 5-year OS and DFS, but the differences were not significant statistically. Conclusion: Clinical size ≥3 cm was a significant prognostic factor for DFS. However, age was the most important prognostic factor for DFS and OS in patients treated with curative RT. Further studies are needed to determine which treatment should be considered for old age ≥70 years.",
author = "Youngkyong Kim and Kim, {Joo Young} and Kim, {Ja Young} and Lee, {Nam Kwon} and Kim, {Jin Hee} and Yongbae Kim and Kim, {Young Seok} and Juree Kim and Kim, {Yeon Sil} and Yang, {Dae Sik} and Kim, {Yeon Joo}",
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Kim, Y, Kim, JY, Kim, JY, Lee, NK, Kim, JH, Kim, Y, Kim, YS, Kim, J, Kim, YS, Yang, DS & Kim, YJ 2015, 'Treatment outcomes of curative radiotherapy in patients with vulvar cancer: Results of the retrospective KROG 1203 study', Radiation Oncology Journal, vol. 33, no. 3, pp. 198-206. https://doi.org/10.3857/roj.2015.33.3.198

Treatment outcomes of curative radiotherapy in patients with vulvar cancer : Results of the retrospective KROG 1203 study. / Kim, Youngkyong; Kim, Joo Young; Kim, Ja Young; Lee, Nam Kwon; Kim, Jin Hee; Kim, Yongbae; Kim, Young Seok; Kim, Juree; Kim, Yeon Sil; Yang, Dae Sik; Kim, Yeon Joo.

In: Radiation Oncology Journal, Vol. 33, No. 3, 01.09.2015, p. 198-206.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Treatment outcomes of curative radiotherapy in patients with vulvar cancer

T2 - Results of the retrospective KROG 1203 study

AU - Kim, Youngkyong

AU - Kim, Joo Young

AU - Kim, Ja Young

AU - Lee, Nam Kwon

AU - Kim, Jin Hee

AU - Kim, Yongbae

AU - Kim, Young Seok

AU - Kim, Juree

AU - Kim, Yeon Sil

AU - Yang, Dae Sik

AU - Kim, Yeon Joo

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Purpose: We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy. Materials and Methods: Overall survival (OS) and disease-free survival (DFS) were assessed retrospectively. Prognostic factors evaluated included age, International Federation of Gynecology and Obstetrics (FIGO) stage, TNM classification, tumor size, treatment modality, RT duration, and RT field. The association between the tumor human papillomavirus (HPV) status and survival was analyzed in 35 patients. Results: During the median follow-up of 2.8 years (range, 0.3 to 18.9 years), 21 patients (37.5%) experienced treatment failure. Fifteen patients (27%) had local failure: nine (16%) local failure only, three (5%) locoregional failure, two (4%) local and distant failure, and one (2%) locoregional and distant failure. Of 56 patients, seven (13%) had persistent disease at the first follow-up at 2 months and all but one died within a year after completing RT. The 5-year OS and DFS were 51.6% and 44.0%, respectively. In multivariate analysis, clinical size ≥3 cm predicted a poor prognostic factor for DFS (p = 0.040) and age (≥70 years) was poor prognostic for DFS (p = 0.032) and OS (p = 0.048). Patients with HPV-positive tumors tended to have better 5-year OS and DFS, but the differences were not significant statistically. Conclusion: Clinical size ≥3 cm was a significant prognostic factor for DFS. However, age was the most important prognostic factor for DFS and OS in patients treated with curative RT. Further studies are needed to determine which treatment should be considered for old age ≥70 years.

AB - Purpose: We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy. Materials and Methods: Overall survival (OS) and disease-free survival (DFS) were assessed retrospectively. Prognostic factors evaluated included age, International Federation of Gynecology and Obstetrics (FIGO) stage, TNM classification, tumor size, treatment modality, RT duration, and RT field. The association between the tumor human papillomavirus (HPV) status and survival was analyzed in 35 patients. Results: During the median follow-up of 2.8 years (range, 0.3 to 18.9 years), 21 patients (37.5%) experienced treatment failure. Fifteen patients (27%) had local failure: nine (16%) local failure only, three (5%) locoregional failure, two (4%) local and distant failure, and one (2%) locoregional and distant failure. Of 56 patients, seven (13%) had persistent disease at the first follow-up at 2 months and all but one died within a year after completing RT. The 5-year OS and DFS were 51.6% and 44.0%, respectively. In multivariate analysis, clinical size ≥3 cm predicted a poor prognostic factor for DFS (p = 0.040) and age (≥70 years) was poor prognostic for DFS (p = 0.032) and OS (p = 0.048). Patients with HPV-positive tumors tended to have better 5-year OS and DFS, but the differences were not significant statistically. Conclusion: Clinical size ≥3 cm was a significant prognostic factor for DFS. However, age was the most important prognostic factor for DFS and OS in patients treated with curative RT. Further studies are needed to determine which treatment should be considered for old age ≥70 years.

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