Treatment outcomes of intensity-modulated radiotherapy versus 3D conformal radiotherapy for patients with maxillary sinus cancer in the postoperative setting

Yang Gun Suh, Chang Geol Lee, Hyunju Kim, Eun Chang Choi, Se Hun Kim, Chang-Hoon Kim, Ki Chang Keum

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma. Methods Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50%) had squamous cell carcinoma and 14 (26%) had adenoid cystic carcinoma. Nineteen patients (35%) were treated with IMRT and 35 patients (65%) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively. Results IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2% vs 59.5%; p =.035) and distant metastasis-free survival (94.7% vs 55.3%; p =.042) rates than 3D conformal RT. Conclusion Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases.

Original languageEnglish
Pages (from-to)E207-E213
JournalHead and Neck
Volume38
DOIs
Publication statusPublished - 2016 Apr 1

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Maxillary Sinus Neoplasms
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Maxillary Sinus
Radiation
Carcinoma
Adenoid Cystic Carcinoma
Survival
Squamous Cell Carcinoma
Radiotherapy
Neoplasm Metastasis
Recurrence

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Suh, Yang Gun ; Lee, Chang Geol ; Kim, Hyunju ; Choi, Eun Chang ; Kim, Se Hun ; Kim, Chang-Hoon ; Keum, Ki Chang. / Treatment outcomes of intensity-modulated radiotherapy versus 3D conformal radiotherapy for patients with maxillary sinus cancer in the postoperative setting. In: Head and Neck. 2016 ; Vol. 38. pp. E207-E213.
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abstract = "Background In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma. Methods Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50{\%}) had squamous cell carcinoma and 14 (26{\%}) had adenoid cystic carcinoma. Nineteen patients (35{\%}) were treated with IMRT and 35 patients (65{\%}) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively. Results IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2{\%} vs 59.5{\%}; p =.035) and distant metastasis-free survival (94.7{\%} vs 55.3{\%}; p =.042) rates than 3D conformal RT. Conclusion Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases.",
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Treatment outcomes of intensity-modulated radiotherapy versus 3D conformal radiotherapy for patients with maxillary sinus cancer in the postoperative setting. / Suh, Yang Gun; Lee, Chang Geol; Kim, Hyunju; Choi, Eun Chang; Kim, Se Hun; Kim, Chang-Hoon; Keum, Ki Chang.

In: Head and Neck, Vol. 38, 01.04.2016, p. E207-E213.

Research output: Contribution to journalArticle

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AU - Suh, Yang Gun

AU - Lee, Chang Geol

AU - Kim, Hyunju

AU - Choi, Eun Chang

AU - Kim, Se Hun

AU - Kim, Chang-Hoon

AU - Keum, Ki Chang

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N2 - Background In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma. Methods Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50%) had squamous cell carcinoma and 14 (26%) had adenoid cystic carcinoma. Nineteen patients (35%) were treated with IMRT and 35 patients (65%) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively. Results IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2% vs 59.5%; p =.035) and distant metastasis-free survival (94.7% vs 55.3%; p =.042) rates than 3D conformal RT. Conclusion Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases.

AB - Background In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma. Methods Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50%) had squamous cell carcinoma and 14 (26%) had adenoid cystic carcinoma. Nineteen patients (35%) were treated with IMRT and 35 patients (65%) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively. Results IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2% vs 59.5%; p =.035) and distant metastasis-free survival (94.7% vs 55.3%; p =.042) rates than 3D conformal RT. Conclusion Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases.

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