Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy

In Young Jung, Moo Hyun Kim, Woo Yong Jeong, Mi Young Ahn, Yong Duk Jeon, Hea Won Ahn, Jin Young Ahn, Je Eun Song, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, June Myung Kim, JunYong Choi

Research output: Contribution to journalArticle

Abstract

Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer. Among them, we selected 15 patients who were culture positive at initial diagnosis and had evidence of active TB on imaging studies; namely, the remaining 97 patients without initial culture or imaging studies were excluded. We thus performed a case-control study of gastric cancer patients treated for TB after undergoing gastrectomy (n = 15). The control group was defined as age- and sex-matched TB patients who had not received gastrectomy (n = 45). Treatment failure in clinical, microbiological aspects, and adverse events were analyzed. Patients who had undergone gastrectomy exhibited higher 4-month clinical failure rates, compared to non-gastrectomy patient: 4 (26.7%) vs. 1 (2.2%), P = 0.012. Gastrointestinal adverse effects were more frequent in patients with gastrectomy, compared to non-gastrectomy patients: 9 (60%) vs. 5 (11.1%), P < 0.001. In conclusion, patients treated for TB after undergoing gastrectomy are associated with higher rates of gastrointestinal adverse events and treatment failure.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume240
Issue number4
DOIs
Publication statusPublished - 2016 Dec 1

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Gastrectomy
Pulmonary Tuberculosis
Imaging techniques
Rifampin
Tuberculosis
Treatment Failure
Stomach Neoplasms
Proxy
Malnutrition
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jung, In Young ; Kim, Moo Hyun ; Jeong, Woo Yong ; Ahn, Mi Young ; Jeon, Yong Duk ; Ahn, Hea Won ; Ahn, Jin Young ; Song, Je Eun ; Oh, Dong Hyun ; Kim, Yong Chan ; Kim, Eun Jin ; Jeong, Su Jin ; Ku, Nam Su ; Kim, June Myung ; Choi, JunYong. / Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy. In: Tohoku Journal of Experimental Medicine. 2016 ; Vol. 240, No. 4. pp. 281-286.
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title = "Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy",
abstract = "Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer. Among them, we selected 15 patients who were culture positive at initial diagnosis and had evidence of active TB on imaging studies; namely, the remaining 97 patients without initial culture or imaging studies were excluded. We thus performed a case-control study of gastric cancer patients treated for TB after undergoing gastrectomy (n = 15). The control group was defined as age- and sex-matched TB patients who had not received gastrectomy (n = 45). Treatment failure in clinical, microbiological aspects, and adverse events were analyzed. Patients who had undergone gastrectomy exhibited higher 4-month clinical failure rates, compared to non-gastrectomy patient: 4 (26.7{\%}) vs. 1 (2.2{\%}), P = 0.012. Gastrointestinal adverse effects were more frequent in patients with gastrectomy, compared to non-gastrectomy patients: 9 (60{\%}) vs. 5 (11.1{\%}), P < 0.001. In conclusion, patients treated for TB after undergoing gastrectomy are associated with higher rates of gastrointestinal adverse events and treatment failure.",
author = "Jung, {In Young} and Kim, {Moo Hyun} and Jeong, {Woo Yong} and Ahn, {Mi Young} and Jeon, {Yong Duk} and Ahn, {Hea Won} and Ahn, {Jin Young} and Song, {Je Eun} and Oh, {Dong Hyun} and Kim, {Yong Chan} and Kim, {Eun Jin} and Jeong, {Su Jin} and Ku, {Nam Su} and Kim, {June Myung} and JunYong Choi",
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Jung, IY, Kim, MH, Jeong, WY, Ahn, MY, Jeon, YD, Ahn, HW, Ahn, JY, Song, JE, Oh, DH, Kim, YC, Kim, EJ, Jeong, SJ, Ku, NS, Kim, JM & Choi, J 2016, 'Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy', Tohoku Journal of Experimental Medicine, vol. 240, no. 4, pp. 281-286. https://doi.org/10.1620/tjem.240.281

Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy. / Jung, In Young; Kim, Moo Hyun; Jeong, Woo Yong; Ahn, Mi Young; Jeon, Yong Duk; Ahn, Hea Won; Ahn, Jin Young; Song, Je Eun; Oh, Dong Hyun; Kim, Yong Chan; Kim, Eun Jin; Jeong, Su Jin; Ku, Nam Su; Kim, June Myung; Choi, JunYong.

In: Tohoku Journal of Experimental Medicine, Vol. 240, No. 4, 01.12.2016, p. 281-286.

Research output: Contribution to journalArticle

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T1 - Treatment outcomes of patients treated for pulmonary tuberculosis after undergoing gastrectomy

AU - Jung, In Young

AU - Kim, Moo Hyun

AU - Jeong, Woo Yong

AU - Ahn, Mi Young

AU - Jeon, Yong Duk

AU - Ahn, Hea Won

AU - Ahn, Jin Young

AU - Song, Je Eun

AU - Oh, Dong Hyun

AU - Kim, Yong Chan

AU - Kim, Eun Jin

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Kim, June Myung

AU - Choi, JunYong

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer. Among them, we selected 15 patients who were culture positive at initial diagnosis and had evidence of active TB on imaging studies; namely, the remaining 97 patients without initial culture or imaging studies were excluded. We thus performed a case-control study of gastric cancer patients treated for TB after undergoing gastrectomy (n = 15). The control group was defined as age- and sex-matched TB patients who had not received gastrectomy (n = 45). Treatment failure in clinical, microbiological aspects, and adverse events were analyzed. Patients who had undergone gastrectomy exhibited higher 4-month clinical failure rates, compared to non-gastrectomy patient: 4 (26.7%) vs. 1 (2.2%), P = 0.012. Gastrointestinal adverse effects were more frequent in patients with gastrectomy, compared to non-gastrectomy patients: 9 (60%) vs. 5 (11.1%), P < 0.001. In conclusion, patients treated for TB after undergoing gastrectomy are associated with higher rates of gastrointestinal adverse events and treatment failure.

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