Treatment outcomes of sinonasal adenoid cystic carcinoma: 30 cases from a single institution

Sang Yeob Seong, Dong Woo Hyun, Yoo Suk Kim, Hyung Ju Cho, Jeung Gweon Lee, Joo Heon Yoon, Chang-Hoon Kim

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Abstract

Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.

Original languageEnglish
JournalJournal of Cranio-Maxillofacial Surgery
Volume42
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Adenoid Cystic Carcinoma
Survival
Recurrence
Neoplasm Metastasis
Disease-Free Survival
Maxillary Sinus
Nasal Cavity
Early Diagnosis
Radiotherapy
Survival Rate
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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Seong, Sang Yeob ; Hyun, Dong Woo ; Kim, Yoo Suk ; Cho, Hyung Ju ; Lee, Jeung Gweon ; Yoon, Joo Heon ; Kim, Chang-Hoon. / Treatment outcomes of sinonasal adenoid cystic carcinoma : 30 cases from a single institution. In: Journal of Cranio-Maxillofacial Surgery. 2014 ; Vol. 42, No. 5.
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abstract = "Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3{\%} and 37.2{\%}, respectively. The maxillary sinus (63.3{\%}) and nasal cavity (23.3{\%}) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0{\%}) and had undergone surgery and postoperative radiotherapy (70.0{\%}). The most common histopathological subtype was cribriform type (40.9{\%}). Local recurrence rate and distant metastasis rates were 26.7{\%} and 23.3{\%}, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.",
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Treatment outcomes of sinonasal adenoid cystic carcinoma : 30 cases from a single institution. / Seong, Sang Yeob; Hyun, Dong Woo; Kim, Yoo Suk; Cho, Hyung Ju; Lee, Jeung Gweon; Yoon, Joo Heon; Kim, Chang-Hoon.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 42, No. 5, 01.01.2014.

Research output: Contribution to journalArticle

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N2 - Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.

AB - Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.

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