Purpose: Acquired epileptic aphasia (AEA) accompanied by electroencephalogram (EEG) abnor-mality is a rare disease; therefore, there are few studies investigating the prognostic factors and treatment efficacy. We aimed to determine the therapeutic effects and prognostic factors for clinical seizure and neuropsychological function in acquired aphasia patients. Methods: We retrospectively studied cases of AEA diagnosed at Severance Children’s Hospital from January 2013 to October 2017. We evaluated the efficacy of antiepileptic drugs, steroids, and ketogenic diets (KD) in treating acquired aphasia. The EEG patterns and prognostic factors were predicted by the background EEG and frequency of spike and wave during sleep (SWS). Results: The study analyzed 20 patients, 11 male and 9 female, with AEA. Aphasia most common-ly occurred at 4 years of age, and clinical seizure was most likely to occur between 2 and 4 years of age and focal seizures were the most common seizure type. KD was shown to be the best treatment for clinical seizure in AEA patients. Patients with normal EEG background showed better responses to clinical seizure treatment and improvements in neuropsychological function. Conclusion: KD and steroids generate the best therapeutic effects for clinical seizure in AEA pa-tients. Improvements in neuropsychological function in AEA patients may be related to the EEG background and the SWS patterns. Additionally, the results suggest that the response of clinical seizure to antiepileptic drugs may also be related to the EEG background. However, the current study had some limitations and further research is needed.
|Number of pages||5|
|Journal||Annals of Child Neurology|
|Publication status||Published - 2019 Jun|
Bibliographical noteFunding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HI18C0586).
This research was supported by a grant of the Korea Health Tech-nology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HI18C0586).
© 2019 Korean Child Neurology Society.
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health