Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid

Junwon Lee, Hee Jung Kwon, Min Kim, Christopher Seungkyu Lee, Sungchul Lee

Research output: Contribution to journalArticle

Abstract

Background: To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth. Methods: Retrospective chart review of 19 patients, who were diagnosed with choroidal neovascularization (CNV)-free small pigmented choroidal lesions and treated with IVB and/or TTT, was performed. Results: Complete resolution of SFF was achieved in two eyes (2/14; 14.3%) after IVB, and in three eyes (3/4; 75%) after TTT. Best corrected visual acuity was improved in two eyes (2/9; 22%) after IVB, and in three eyes (3/4; 75%) after TTT. Among five patients who underwent TTT after IVB, four patients (4/5; 80%) demonstrated additional advantage. All IVBs could not reduce tumor sizes. Rather, tumor growth was detected in seven out of 14 eyes (7/14; 50%) that underwent IVB. None of the patients who underwent TTT showed tumor growth. The lack of treatment response to IVB was suggestive of malignancy, as most small pigmented lesions that had no response to IVB showed tumor growth (86%, p = 0.010). Conclusion: IVB was not effective in reducing tumor size and subfoveal fluid in small pigmented choroidal lesions. Therapeutic response to IVB can be used as an indicator between melanoma and nevus in small pigmented choroidal lesion.

Original languageEnglish
Article number103
JournalBMC Ophthalmology
Volume19
Issue number1
DOIs
Publication statusPublished - 2019 May 3

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Subretinal Fluid
Intravitreal Injections
Induced Hyperthermia
Neoplasms
Therapeutics
Growth
Bevacizumab
Nevi and Melanomas
Choroidal Neovascularization
Visual Acuity

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Lee, Junwon ; Kwon, Hee Jung ; Kim, Min ; Lee, Christopher Seungkyu ; Lee, Sungchul. / Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid. In: BMC Ophthalmology. 2019 ; Vol. 19, No. 1.
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abstract = "Background: To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth. Methods: Retrospective chart review of 19 patients, who were diagnosed with choroidal neovascularization (CNV)-free small pigmented choroidal lesions and treated with IVB and/or TTT, was performed. Results: Complete resolution of SFF was achieved in two eyes (2/14; 14.3{\%}) after IVB, and in three eyes (3/4; 75{\%}) after TTT. Best corrected visual acuity was improved in two eyes (2/9; 22{\%}) after IVB, and in three eyes (3/4; 75{\%}) after TTT. Among five patients who underwent TTT after IVB, four patients (4/5; 80{\%}) demonstrated additional advantage. All IVBs could not reduce tumor sizes. Rather, tumor growth was detected in seven out of 14 eyes (7/14; 50{\%}) that underwent IVB. None of the patients who underwent TTT showed tumor growth. The lack of treatment response to IVB was suggestive of malignancy, as most small pigmented lesions that had no response to IVB showed tumor growth (86{\%}, p = 0.010). Conclusion: IVB was not effective in reducing tumor size and subfoveal fluid in small pigmented choroidal lesions. Therapeutic response to IVB can be used as an indicator between melanoma and nevus in small pigmented choroidal lesion.",
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Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid. / Lee, Junwon; Kwon, Hee Jung; Kim, Min; Lee, Christopher Seungkyu; Lee, Sungchul.

In: BMC Ophthalmology, Vol. 19, No. 1, 103, 03.05.2019.

Research output: Contribution to journalArticle

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T1 - Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid

AU - Lee, Junwon

AU - Kwon, Hee Jung

AU - Kim, Min

AU - Lee, Christopher Seungkyu

AU - Lee, Sungchul

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