Treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma: A single institution experience

Hyun Jik Lee, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background/Aims: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. Methods: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. Results: The mean tumor size was 11.5±5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8%) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2%). The en bloc resection rate and complete resection rate were 91.9% and 81.8%, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5%), lamina propria mucosa in 12 cases (32.4%), muscularis mucosa in 10 cases (27.0%) and submucosa in 10 cases (27.0%). The complication rate was 13.5% and included three cases (8.1%) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. Conclusions: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an accept-able oncologic outcome in early esophageal carcinoma.

Original languageEnglish
Pages (from-to)714-719
Number of pages6
JournalGut and liver
Volume9
Issue number6
DOIs
Publication statusPublished - 2015 Nov

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Mucous Membrane
Radiotherapy
Therapeutics
Esophagectomy
Chemoradiotherapy
Esophageal Squamous Cell Carcinoma
Neoplasms
Neoplasm Metastasis
Carcinoma
Recurrence
Endoscopic Mucosal Resection

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{9824697bc2d249d085bae730ecba6d4f,
title = "Treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma: A single institution experience",
abstract = "Background/Aims: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. Methods: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. Results: The mean tumor size was 11.5±5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8{\%}) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2{\%}). The en bloc resection rate and complete resection rate were 91.9{\%} and 81.8{\%}, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5{\%}), lamina propria mucosa in 12 cases (32.4{\%}), muscularis mucosa in 10 cases (27.0{\%}) and submucosa in 10 cases (27.0{\%}). The complication rate was 13.5{\%} and included three cases (8.1{\%}) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. Conclusions: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an accept-able oncologic outcome in early esophageal carcinoma.",
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Treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma : A single institution experience. / Lee, Hyun Jik; Lee, Hyuk; Park, Jun Chul; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan.

In: Gut and liver, Vol. 9, No. 6, 11.2015, p. 714-719.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma

T2 - A single institution experience

AU - Lee, Hyun Jik

AU - Lee, Hyuk

AU - Park, Jun Chul

AU - Shin, Sung Kwan

AU - Lee, Sang Kil

AU - Lee, Yong Chan

PY - 2015/11

Y1 - 2015/11

N2 - Background/Aims: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. Methods: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. Results: The mean tumor size was 11.5±5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8%) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2%). The en bloc resection rate and complete resection rate were 91.9% and 81.8%, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5%), lamina propria mucosa in 12 cases (32.4%), muscularis mucosa in 10 cases (27.0%) and submucosa in 10 cases (27.0%). The complication rate was 13.5% and included three cases (8.1%) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. Conclusions: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an accept-able oncologic outcome in early esophageal carcinoma.

AB - Background/Aims: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. Methods: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. Results: The mean tumor size was 11.5±5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8%) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2%). The en bloc resection rate and complete resection rate were 91.9% and 81.8%, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5%), lamina propria mucosa in 12 cases (32.4%), muscularis mucosa in 10 cases (27.0%) and submucosa in 10 cases (27.0%). The complication rate was 13.5% and included three cases (8.1%) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. Conclusions: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an accept-able oncologic outcome in early esophageal carcinoma.

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SN - 1976-2283

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