Abstract
In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.
| Original language | English |
|---|---|
| Pages (from-to) | 174-178 |
| Number of pages | 5 |
| Journal | Acta dermato-venereologica |
| Volume | 82 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 Aug 15 |
All Science Journal Classification (ASJC) codes
- Dermatology
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Kee, Y. C., Kim, K. S., Min, G. L., Nam, S. C., & Jung, B. L. (2002). Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts. Acta dermato-venereologica, 82(3), 174-178. https://doi.org/10.1080/00015550260132442