Abstract
In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.
Original language | English |
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Pages (from-to) | 174-178 |
Number of pages | 5 |
Journal | Acta dermato-venereologica |
Volume | 82 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2002 |
All Science Journal Classification (ASJC) codes
- Dermatology