Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts

Yang Chung Kee, Kyung Sup Kim, Mingeol Lee, Soo Chang Nam, Bock Lee Jung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalActa Dermato-Venereologica
Volume82
Issue number3
DOIs
Publication statusPublished - 2002 Aug 15

Fingerprint

Treponema pallidum
Matrix Metalloproteinase 1
Up-Regulation
Fibroblasts
Matrix Metalloproteinases
Skin
Virulence Factors
Dermis
Collagen Type I
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kee, Yang Chung ; Kim, Kyung Sup ; Lee, Mingeol ; Nam, Soo Chang ; Jung, Bock Lee. / Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts. In: Acta Dermato-Venereologica. 2002 ; Vol. 82, No. 3. pp. 174-178.
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Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts. / Kee, Yang Chung; Kim, Kyung Sup; Lee, Mingeol; Nam, Soo Chang; Jung, Bock Lee.

In: Acta Dermato-Venereologica, Vol. 82, No. 3, 15.08.2002, p. 174-178.

Research output: Contribution to journalArticle

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