Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts

Yang Chung Kee, Kyung Sup Kim, Geol Lee Min, Soo Chang Nam, Bock Lee Jung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalActa dermato-venereologica
Volume82
Issue number3
DOIs
Publication statusPublished - 2002 Aug 15

All Science Journal Classification (ASJC) codes

  • Dermatology

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