Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts

Yang Chung Kee; Kyung Sup Kim; Geol Lee Min; Soo Chang Nam; Bock Lee Jung

doi:10.1080/00015550260132442

Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts

Yang Chung Kee, Kyung Sup Kim, Geol Lee Min, Soo Chang Nam, Bock Lee Jung

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.

Original language	English
Pages (from-to)	174-178
Number of pages	5
Journal	Acta dermato-venereologica
Volume	82
Issue number	3
DOIs	https://doi.org/10.1080/00015550260132442
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Dermatology

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10.1080/00015550260132442

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AU - Jung, Bock Lee

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AB - In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.

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