Abstract
In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.
| Original language | English |
|---|---|
| Pages (from-to) | 174-178 |
| Number of pages | 5 |
| Journal | Acta Dermato-Venereologica |
| Volume | 82 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 Aug 15 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts. / Kee, Yang Chung; Kim, Kyung Sup; Lee, Mingeol; Nam, Soo Chang; Jung, Bock Lee.
In: Acta Dermato-Venereologica, Vol. 82, No. 3, 15.08.2002, p. 174-178.Research output: Contribution to journal › Article
TY - JOUR
T1 - Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts
AU - Kee, Yang Chung
AU - Kim, Kyung Sup
AU - Lee, Mingeol
AU - Nam, Soo Chang
AU - Jung, Bock Lee
PY - 2002/8/15
Y1 - 2002/8/15
N2 - In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.
AB - In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036364646&partnerID=8YFLogxK
U2 - 10.1080/00015550260132442
DO - 10.1080/00015550260132442
M3 - Article
VL - 82
SP - 174
EP - 178
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 3
ER -