Triboelectric Nanogenerator Accelerates Highly Efficient Nonviral Direct Conversion and In Vivo Reprogramming of Fibroblasts to Functional Neuronal Cells

Yoonhee Jin, Jungmok Seo, Jung Seung Lee, Sera Shin, Hyun Ji Park, Sungjin Min, Eunji Cheong, Taeyoon Lee, Seung-Woo Cho

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion efficiency, and induces highly matured neuronal phenotypes with improved electrophysiological functionalities. TENG devices may also be used for biomedical in vivo reprogramming.

Original languageEnglish
Pages (from-to)7365-7374
Number of pages10
JournalAdvanced materials (Deerfield Beach, Fla.)
Volume28
Issue number34
DOIs
Publication statusPublished - 2016 Sep 1

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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