Abstract
We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.
Original language | English |
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Pages (from-to) | 683-685 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2010 Jan 27 |
Bibliographical note
Funding Information:This work was supported by the Center for Bioactive Molecular Hybrids.
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry