Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Joong Gon Kim, Doo Ok Jang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number4
DOIs
Publication statusPublished - 2010 Jan 27

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine'. Together they form a unique fingerprint.

  • Cite this