Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Joong Gon Kim; Doo Ok Jang

doi:10.1016/j.tetlet.2009.11.105

Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Joong Gon Kim, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2009.11.105
Publication status	Published - 2010 Jan 27

Bibliographical note

Funding Information:
This work was supported by the Center for Bioactive Molecular Hybrids.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.11.105

Cite this

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abstract = "We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.",

author = "Kim, {Joong Gon} and Jang, {Doo Ok}",

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AU - Kim, Joong Gon

AU - Jang, Doo Ok

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PY - 2010/1/27

Y1 - 2010/1/27

N2 - We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

AB - We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

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JO - Tetrahedron Letters

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Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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