Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Joong Gon Kim, Doo Ok Jang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number4
DOIs
Publication statusPublished - 2010 Jan 27

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Trifluoroacetic Acid
Amines
triphenylphosphine
trichloroacetonitrile

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine. / Kim, Joong Gon; Jang, Doo Ok.

In: Tetrahedron Letters, Vol. 51, No. 4, 27.01.2010, p. 683-685.

Research output: Contribution to journalArticle

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