Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

Joong Gon Kim, Doo Ok Jang

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number4
DOIs
Publication statusPublished - 2010 Jan 27

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Trifluoroacetic Acid
Amines
triphenylphosphine
trichloroacetonitrile

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Kim, Joong Gon ; Jang, Doo Ok. / Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 4. pp. 683-685.
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Kim, JG & Jang, DO 2010, 'Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine', Tetrahedron Letters, vol. 51, no. 4, pp. 683-685. https://doi.org/10.1016/j.tetlet.2009.11.105

Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine. / Kim, Joong Gon; Jang, Doo Ok.

In: Tetrahedron Letters, Vol. 51, No. 4, 27.01.2010, p. 683-685.

Research output: Contribution to journal › Article

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AU - Jang, Doo Ok

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Kim JG, Jang DO. Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine. Tetrahedron Letters. 2010 Jan 27;51(4):683-685. https://doi.org/10.1016/j.tetlet.2009.11.105

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