We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.
Bibliographical noteFunding Information:
This work was supported by the Center for Bioactive Molecular Hybrids.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry