Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8–5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.
Bibliographical noteFunding Information:
The authors would like to thank those who participated in the KoGES. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. None. T.K.L. conceptualized and designed the study; collected, analyzed, and interpreted the data; wrote the first draft and revised later drafts of the manuscript. T.K.L. and H.S.L. analyzed and interpreted the data, and performed the statistical analysis. Y.J.L. revised the article. Y.J.L. is the guarantor of this work and, as such, had full access to all of the data in the study and take responsibility for its integrity, and the accuracy of the data analysis. The dataset used in this study (Ansan-Ansung cohort) can be provided after review and evaluation of research plan by the Korea Centers for Disease Control and Prevention (http://www.cdc.go.kr/CDC/eng/main.jsp).
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism