Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: The Kangwha study

Hyungseon Yeom, Hyeon Chang Kim, Ju Mi Lee, Yongwoo Jeon, Il Suh

Research output: Contribution to journalArticle

Abstract

Background: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. Methods: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure ≥ 140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels. Results: During the 20-year follow-up, 11 (18.3%) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4%) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95% confidence interval 1.24-9.31). Conclusions: High TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood.

Original languageEnglish
Article number212
JournalLipids in Health and Disease
Volume17
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

HDL Cholesterol
Triglycerides
Hypertension
Blood pressure
Blood Pressure
Waist Circumference
Regression analysis
Antihypertensive Agents
Population
Logistics
Fasting
Cohort Studies
Logistic Models
Odds Ratio
Cholesterol
Regression Analysis
Health
Prospective Studies
Confidence Intervals
Students

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{d630509dc45e447d9817aea2b84b5b26,
title = "Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: The Kangwha study",
abstract = "Background: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. Methods: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure ≥ 140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels. Results: During the 20-year follow-up, 11 (18.3{\%}) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4{\%}) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95{\%} confidence interval 1.24-9.31). Conclusions: High TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood.",
author = "Hyungseon Yeom and Kim, {Hyeon Chang} and Lee, {Ju Mi} and Yongwoo Jeon and Il Suh",
year = "2018",
month = "1",
day = "1",
doi = "10.1186/s12944-018-0861-y",
language = "English",
volume = "17",
journal = "Lipids in Health and Disease",
issn = "1476-511X",
publisher = "BioMed Central",
number = "1",

}

Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension : The Kangwha study. / Yeom, Hyungseon; Kim, Hyeon Chang; Lee, Ju Mi; Jeon, Yongwoo; Suh, Il.

In: Lipids in Health and Disease, Vol. 17, No. 1, 212, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension

T2 - The Kangwha study

AU - Yeom, Hyungseon

AU - Kim, Hyeon Chang

AU - Lee, Ju Mi

AU - Jeon, Yongwoo

AU - Suh, Il

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. Methods: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure ≥ 140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels. Results: During the 20-year follow-up, 11 (18.3%) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4%) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95% confidence interval 1.24-9.31). Conclusions: High TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood.

AB - Background: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. Methods: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure ≥ 140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels. Results: During the 20-year follow-up, 11 (18.3%) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4%) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95% confidence interval 1.24-9.31). Conclusions: High TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood.

UR - http://www.scopus.com/inward/record.url?scp=85059797678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059797678&partnerID=8YFLogxK

U2 - 10.1186/s12944-018-0861-y

DO - 10.1186/s12944-018-0861-y

M3 - Article

C2 - 30200983

AN - SCOPUS:85059797678

VL - 17

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

SN - 1476-511X

IS - 1

M1 - 212

ER -