Abstract
Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.
| Original language | English |
|---|---|
| Journal | Obesity Research and Clinical Practice |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
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Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects : T3 and visceral obesity. / Nam, Ji Sun; Cho, Minho; Park, Jong Suk; Ahn, Chul Woo; Cha, Bong Soo; Lee, Eunjig; Lim, Sungkil; Kim, Kyung Rae; Lee, Hyun Chul.
In: Obesity Research and Clinical Practice, Vol. 4, No. 4, 01.01.2010.Research output: Contribution to journal › Article
TY - JOUR
T1 - Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects
T2 - T3 and visceral obesity
AU - Nam, Ji Sun
AU - Cho, Minho
AU - Park, Jong Suk
AU - Ahn, Chul Woo
AU - Cha, Bong Soo
AU - Lee, Eunjig
AU - Lim, Sungkil
AU - Kim, Kyung Rae
AU - Lee, Hyun Chul
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.
AB - Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.
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U2 - 10.1016/j.orcp.2010.08.003
DO - 10.1016/j.orcp.2010.08.003
M3 - Article
VL - 4
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
SN - 1871-403X
IS - 4
ER -