Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects

T3 and visceral obesity

Ji Sun Nam, Minho Cho, Jong Suk Park, Chul Woo Ahn, Bong Soo Cha, Eunjig Lee, Sungkil Lim, Kyung Rae Kim, Hyun Chul Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.

Original languageEnglish
JournalObesity Research and Clinical Practice
Volume4
Issue number4
DOIs
Publication statusPublished - 2010 Jan 1

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Intra-Abdominal Fat
Abdominal Obesity
Triiodothyronine
Pulse Wave Analysis
Atherosclerosis
Adipose Tissue
Subcutaneous Fat
Thyroid Hormones
Abdominal Fat
Waist Circumference
Energy Metabolism
Obesity
Tomography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Nam, Ji Sun ; Cho, Minho ; Park, Jong Suk ; Ahn, Chul Woo ; Cha, Bong Soo ; Lee, Eunjig ; Lim, Sungkil ; Kim, Kyung Rae ; Lee, Hyun Chul. / Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects : T3 and visceral obesity. In: Obesity Research and Clinical Practice. 2010 ; Vol. 4, No. 4.
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abstract = "Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.",
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Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects : T3 and visceral obesity. / Nam, Ji Sun; Cho, Minho; Park, Jong Suk; Ahn, Chul Woo; Cha, Bong Soo; Lee, Eunjig; Lim, Sungkil; Kim, Kyung Rae; Lee, Hyun Chul.

In: Obesity Research and Clinical Practice, Vol. 4, No. 4, 01.01.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Triiodothyronine level predicts visceral obesity and atherosclerosis in euthyroid, overweight and obese subjects

T2 - T3 and visceral obesity

AU - Nam, Ji Sun

AU - Cho, Minho

AU - Park, Jong Suk

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Lee, Eunjig

AU - Lim, Sungkil

AU - Kim, Kyung Rae

AU - Lee, Hyun Chul

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.

AB - Objective: We assessed how thyroid hormones affect the visceral obesity and atherosclerosis in euthyroid, overweight and obese Asian subjects. Methods: Metabolic parameters and thyroid hormone levels were measured in 177 subjects who visited obesity clinic at Gangnam Severance Hospital. Total adipose tissue area (TAT), subcutaneous adipose tissue area (SAT), visceral adipose tissue area (VAT) were quantified by computerized tomography scan, and, pulse wave velocity (PWV) was measured as a marker of atherosclerosis. Results: T3 was significantly related to all the measures of abdominal fat, TAT (P= 0.001), SAT (P = 0.015), VAT (P< 0.001), and waist circumference (P = 0.001) as well as BMI (P = 0.017) and total body fat percent (P= 0.001) after adjusting for age and sex. In multiple regression analysis, T3 was independently associated with VAT (̌ =0.486, P= 0.009). There was a positive correlation between T3 and PWV. Conclusions: T3 level is positively associated with the amount of visceral fat and PWV. Visceral obesity seems to cause an increase in circulating T3 level as an adaptational response to increase the energy expenditure, and thus a more close attention and an effort to assess cardiovascular risks should be made to people with high normal T3 level.

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