Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

Dinneswara Reddy Guda; Tengjiao Wang; Hyeon Mo Cho; Myong Euy Lee

doi:10.1016/j.tetlet.2012.07.054

Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

Dinneswara Reddy Guda, Tengjiao Wang, Hyeon Mo Cho, Myong Euy Lee

University College

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.

Original language	English
Pages (from-to)	5238-5242
Number of pages	5
Journal	Tetrahedron Letters
Volume	53
Issue number	39
DOIs	https://doi.org/10.1016/j.tetlet.2012.07.054
Publication status	Published - 2012 Sept 26

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0024877). We thank Professor Robert West, distinguished Professor in the WCU program for his valuable discussion. D.R. Guda also thanks BK-21 funds for the financial support of his post-doc position.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2012.07.054

Cite this

@article{e818b0fe5d934794af5b49d712d0a3fd,

title = "Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles",

abstract = "A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.",

author = "Guda, {Dinneswara Reddy} and Tengjiao Wang and Cho, {Hyeon Mo} and Lee, {Myong Euy}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0024877). We thank Professor Robert West, distinguished Professor in the WCU program for his valuable discussion. D.R. Guda also thanks BK-21 funds for the financial support of his post-doc position. ",

year = "2012",

month = sep,

day = "26",

doi = "10.1016/j.tetlet.2012.07.054",

language = "English",

volume = "53",

pages = "5238--5242",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "39",

}

TY - JOUR

T1 - Trimethylsilyl isothiocyanate (TMSNCS)

T2 - An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

AU - Guda, Dinneswara Reddy

AU - Wang, Tengjiao

AU - Cho, Hyeon Mo

AU - Lee, Myong Euy

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0024877). We thank Professor Robert West, distinguished Professor in the WCU program for his valuable discussion. D.R. Guda also thanks BK-21 funds for the financial support of his post-doc position.

PY - 2012/9/26

Y1 - 2012/9/26

N2 - A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.

AB - A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.

UR - http://www.scopus.com/inward/record.url?scp=84865471726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865471726&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2012.07.054

DO - 10.1016/j.tetlet.2012.07.054

M3 - Article

AN - SCOPUS:84865471726

SN - 0040-4039

VL - 53

SP - 5238

EP - 5242

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this