Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

Dinneswara Reddy Guda, Tengjiao Wang, Hyeon Mo Cho, Myong Euy Lee

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24 Citations (Scopus)


A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.

Original languageEnglish
Pages (from-to)5238-5242
Number of pages5
JournalTetrahedron Letters
Issue number39
Publication statusPublished - 2012 Sept 26

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0024877). We thank Professor Robert West, distinguished Professor in the WCU program for his valuable discussion. D.R. Guda also thanks BK-21 funds for the financial support of his post-doc position.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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