Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

Seong Hwan Kim, So Hee Kwon, Seon Hui Park, Jae Kyun Lee, Hea Son Bang, Sang Jip Nam, Hak Cheol Kwon, Jongheon Shin, Dong Chan Oh

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Abstract

Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

Original languageEnglish
Pages (from-to)1834-1837
Number of pages4
JournalOrganic Letters
Volume15
Issue number8
DOIs
Publication statusPublished - 2013 Apr 19

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Kim, S. H., Kwon, S. H., Park, S. H., Lee, J. K., Bang, H. S., Nam, S. J., Kwon, H. C., Shin, J., & Oh, D. C. (2013). Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva. Organic Letters, 15(8), 1834-1837. https://doi.org/10.1021/ol4004417