Triphasic mitral inflow velocity with mid-diastolic flow: The presence of mid-diastolic mitral annular velocity indicates advanced diastolic dysfunction

Jong Won Ha, Jeong Ahn Ahn, Jae Yun Moon, Hye Sun Suh, seokmin kang, Se Joong Rim, Yangsoo Jang, Namsik Chung, Won Heun Shim, Seong Yun Cho

Research output: Contribution to journalArticle

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Abstract

Mitral inflow filling pattern usually consists of 2 forward flow velocities in sinus rhythm: early rapid filling (E) and late filling with atrial contraction (A). However, additional mid-diastolic flow velocity may be present resulting in triphasic mitral inflow filling pattern. When mitral inflow is triphasic, mitral annulus velocity recorded by tissue Doppler imaging (TDI) frequently demonstrates a mid-diastolic component (L′). The significance of L′ has not been explored previously. The purpose of this study was to explore possible mechanisms and clinical implications of triphasic mitral inflow with or without L′ using TDI and proBNP. Of 9004 patients who underwent transthoracic echocardiography from March to November 2003, 83 (0.9%) patients (33 male, 50 female; mean age, 63 ± 10 years) with a triphasic mitral inflow velocity pattern, including mid-diastolic flow velocity of at least 0.2 m/s, and sinus rhythm were prospectively identified in our clinical echocardiography laboratory. Peak velocity of E, mid-diastolic (L), and A, and deceleration time (DT) of the E wave velocity were measured. Diastolic mitral annular velocities were measured at the septal corner of the mitral annulus by TDI from the apical 4-chamber view. ProBNP was measured at the time of echocardiogram using a quantitative electrochemiluminescence immunoassay. Mean heart rate was 54 ± 6 beats/min (range, 40-67). Mean left ventricular (LV) ejection fraction (EF) was 64 ± 13% and LV systolic dysfunction (EF < 40%) was present in only 6 (7%). Patients were classified into 2 groups: group 1 (n = 47) included those who had L′ and group 2 (n = 36) included those without L′. Group 1 patients had significantly higher peak velocity (35 ± 14 vs 26 ± 6 cm/s, p = 0.0002) and TVI (35 ± 14 vs 26 ± 6 cm/ s, p = 0.0002) of L, E/E′ (18 ± 8 vs 14 ± 6, p = 0.02), and left atrial volume index (42 ± 14 vs 34 ± 10 ml/ m2, p = 0.0037). E′ (4.7 ± 1.3 vs 6.2 ± 2.3 cm/s, p = 0.001) and A′ (6.2 ± 2.0 vs 8.6 ± 3.4 cm/s, p = 0.0006) were significantly lower in group 1 compared with those of group 2. ProBNP was significantly higher in group 1 (847 ± 1461 vs 438 ± 1039 pmol/l, p = 0.0012) and it was above normal in all except in 1 patient of group 1. In conclusion, the presence of L′ in subjects with triphasic mitral inflow velocity pattern with mid-diastolic flow is associated with higher E/E′, elevated proBNP and enlarged left atrium indicating advanced diastolic dysfunction with elevated filling pressures. This unique mitral annular velocity pattern should be helpful in identifying the patients with advanced diastolic dysfunction and increased LV filling pressures.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalEuropean Journal of Echocardiography
Volume7
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

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Echocardiography
Deceleration
Left Ventricular Dysfunction
Ventricular Pressure
Heart Atria
Immunoassay
Stroke Volume
Heart Rate
Pressure

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Ha, Jong Won ; Ahn, Jeong Ahn ; Moon, Jae Yun ; Suh, Hye Sun ; kang, seokmin ; Rim, Se Joong ; Jang, Yangsoo ; Chung, Namsik ; Shim, Won Heun ; Cho, Seong Yun. / Triphasic mitral inflow velocity with mid-diastolic flow : The presence of mid-diastolic mitral annular velocity indicates advanced diastolic dysfunction. In: European Journal of Echocardiography. 2006 ; Vol. 7, No. 1. pp. 16-21.
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abstract = "Mitral inflow filling pattern usually consists of 2 forward flow velocities in sinus rhythm: early rapid filling (E) and late filling with atrial contraction (A). However, additional mid-diastolic flow velocity may be present resulting in triphasic mitral inflow filling pattern. When mitral inflow is triphasic, mitral annulus velocity recorded by tissue Doppler imaging (TDI) frequently demonstrates a mid-diastolic component (L′). The significance of L′ has not been explored previously. The purpose of this study was to explore possible mechanisms and clinical implications of triphasic mitral inflow with or without L′ using TDI and proBNP. Of 9004 patients who underwent transthoracic echocardiography from March to November 2003, 83 (0.9{\%}) patients (33 male, 50 female; mean age, 63 ± 10 years) with a triphasic mitral inflow velocity pattern, including mid-diastolic flow velocity of at least 0.2 m/s, and sinus rhythm were prospectively identified in our clinical echocardiography laboratory. Peak velocity of E, mid-diastolic (L), and A, and deceleration time (DT) of the E wave velocity were measured. Diastolic mitral annular velocities were measured at the septal corner of the mitral annulus by TDI from the apical 4-chamber view. ProBNP was measured at the time of echocardiogram using a quantitative electrochemiluminescence immunoassay. Mean heart rate was 54 ± 6 beats/min (range, 40-67). Mean left ventricular (LV) ejection fraction (EF) was 64 ± 13{\%} and LV systolic dysfunction (EF < 40{\%}) was present in only 6 (7{\%}). Patients were classified into 2 groups: group 1 (n = 47) included those who had L′ and group 2 (n = 36) included those without L′. Group 1 patients had significantly higher peak velocity (35 ± 14 vs 26 ± 6 cm/s, p = 0.0002) and TVI (35 ± 14 vs 26 ± 6 cm/ s, p = 0.0002) of L, E/E′ (18 ± 8 vs 14 ± 6, p = 0.02), and left atrial volume index (42 ± 14 vs 34 ± 10 ml/ m2, p = 0.0037). E′ (4.7 ± 1.3 vs 6.2 ± 2.3 cm/s, p = 0.001) and A′ (6.2 ± 2.0 vs 8.6 ± 3.4 cm/s, p = 0.0006) were significantly lower in group 1 compared with those of group 2. ProBNP was significantly higher in group 1 (847 ± 1461 vs 438 ± 1039 pmol/l, p = 0.0012) and it was above normal in all except in 1 patient of group 1. In conclusion, the presence of L′ in subjects with triphasic mitral inflow velocity pattern with mid-diastolic flow is associated with higher E/E′, elevated proBNP and enlarged left atrium indicating advanced diastolic dysfunction with elevated filling pressures. This unique mitral annular velocity pattern should be helpful in identifying the patients with advanced diastolic dysfunction and increased LV filling pressures.",
author = "Ha, {Jong Won} and Ahn, {Jeong Ahn} and Moon, {Jae Yun} and Suh, {Hye Sun} and seokmin kang and Rim, {Se Joong} and Yangsoo Jang and Namsik Chung and Shim, {Won Heun} and Cho, {Seong Yun}",
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Triphasic mitral inflow velocity with mid-diastolic flow : The presence of mid-diastolic mitral annular velocity indicates advanced diastolic dysfunction. / Ha, Jong Won; Ahn, Jeong Ahn; Moon, Jae Yun; Suh, Hye Sun; kang, seokmin; Rim, Se Joong; Jang, Yangsoo; Chung, Namsik; Shim, Won Heun; Cho, Seong Yun.

In: European Journal of Echocardiography, Vol. 7, No. 1, 01.01.2006, p. 16-21.

Research output: Contribution to journalArticle

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T1 - Triphasic mitral inflow velocity with mid-diastolic flow

T2 - The presence of mid-diastolic mitral annular velocity indicates advanced diastolic dysfunction

AU - Ha, Jong Won

AU - Ahn, Jeong Ahn

AU - Moon, Jae Yun

AU - Suh, Hye Sun

AU - kang, seokmin

AU - Rim, Se Joong

AU - Jang, Yangsoo

AU - Chung, Namsik

AU - Shim, Won Heun

AU - Cho, Seong Yun

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Mitral inflow filling pattern usually consists of 2 forward flow velocities in sinus rhythm: early rapid filling (E) and late filling with atrial contraction (A). However, additional mid-diastolic flow velocity may be present resulting in triphasic mitral inflow filling pattern. When mitral inflow is triphasic, mitral annulus velocity recorded by tissue Doppler imaging (TDI) frequently demonstrates a mid-diastolic component (L′). The significance of L′ has not been explored previously. The purpose of this study was to explore possible mechanisms and clinical implications of triphasic mitral inflow with or without L′ using TDI and proBNP. Of 9004 patients who underwent transthoracic echocardiography from March to November 2003, 83 (0.9%) patients (33 male, 50 female; mean age, 63 ± 10 years) with a triphasic mitral inflow velocity pattern, including mid-diastolic flow velocity of at least 0.2 m/s, and sinus rhythm were prospectively identified in our clinical echocardiography laboratory. Peak velocity of E, mid-diastolic (L), and A, and deceleration time (DT) of the E wave velocity were measured. Diastolic mitral annular velocities were measured at the septal corner of the mitral annulus by TDI from the apical 4-chamber view. ProBNP was measured at the time of echocardiogram using a quantitative electrochemiluminescence immunoassay. Mean heart rate was 54 ± 6 beats/min (range, 40-67). Mean left ventricular (LV) ejection fraction (EF) was 64 ± 13% and LV systolic dysfunction (EF < 40%) was present in only 6 (7%). Patients were classified into 2 groups: group 1 (n = 47) included those who had L′ and group 2 (n = 36) included those without L′. Group 1 patients had significantly higher peak velocity (35 ± 14 vs 26 ± 6 cm/s, p = 0.0002) and TVI (35 ± 14 vs 26 ± 6 cm/ s, p = 0.0002) of L, E/E′ (18 ± 8 vs 14 ± 6, p = 0.02), and left atrial volume index (42 ± 14 vs 34 ± 10 ml/ m2, p = 0.0037). E′ (4.7 ± 1.3 vs 6.2 ± 2.3 cm/s, p = 0.001) and A′ (6.2 ± 2.0 vs 8.6 ± 3.4 cm/s, p = 0.0006) were significantly lower in group 1 compared with those of group 2. ProBNP was significantly higher in group 1 (847 ± 1461 vs 438 ± 1039 pmol/l, p = 0.0012) and it was above normal in all except in 1 patient of group 1. In conclusion, the presence of L′ in subjects with triphasic mitral inflow velocity pattern with mid-diastolic flow is associated with higher E/E′, elevated proBNP and enlarged left atrium indicating advanced diastolic dysfunction with elevated filling pressures. This unique mitral annular velocity pattern should be helpful in identifying the patients with advanced diastolic dysfunction and increased LV filling pressures.

AB - Mitral inflow filling pattern usually consists of 2 forward flow velocities in sinus rhythm: early rapid filling (E) and late filling with atrial contraction (A). However, additional mid-diastolic flow velocity may be present resulting in triphasic mitral inflow filling pattern. When mitral inflow is triphasic, mitral annulus velocity recorded by tissue Doppler imaging (TDI) frequently demonstrates a mid-diastolic component (L′). The significance of L′ has not been explored previously. The purpose of this study was to explore possible mechanisms and clinical implications of triphasic mitral inflow with or without L′ using TDI and proBNP. Of 9004 patients who underwent transthoracic echocardiography from March to November 2003, 83 (0.9%) patients (33 male, 50 female; mean age, 63 ± 10 years) with a triphasic mitral inflow velocity pattern, including mid-diastolic flow velocity of at least 0.2 m/s, and sinus rhythm were prospectively identified in our clinical echocardiography laboratory. Peak velocity of E, mid-diastolic (L), and A, and deceleration time (DT) of the E wave velocity were measured. Diastolic mitral annular velocities were measured at the septal corner of the mitral annulus by TDI from the apical 4-chamber view. ProBNP was measured at the time of echocardiogram using a quantitative electrochemiluminescence immunoassay. Mean heart rate was 54 ± 6 beats/min (range, 40-67). Mean left ventricular (LV) ejection fraction (EF) was 64 ± 13% and LV systolic dysfunction (EF < 40%) was present in only 6 (7%). Patients were classified into 2 groups: group 1 (n = 47) included those who had L′ and group 2 (n = 36) included those without L′. Group 1 patients had significantly higher peak velocity (35 ± 14 vs 26 ± 6 cm/s, p = 0.0002) and TVI (35 ± 14 vs 26 ± 6 cm/ s, p = 0.0002) of L, E/E′ (18 ± 8 vs 14 ± 6, p = 0.02), and left atrial volume index (42 ± 14 vs 34 ± 10 ml/ m2, p = 0.0037). E′ (4.7 ± 1.3 vs 6.2 ± 2.3 cm/s, p = 0.001) and A′ (6.2 ± 2.0 vs 8.6 ± 3.4 cm/s, p = 0.0006) were significantly lower in group 1 compared with those of group 2. ProBNP was significantly higher in group 1 (847 ± 1461 vs 438 ± 1039 pmol/l, p = 0.0012) and it was above normal in all except in 1 patient of group 1. In conclusion, the presence of L′ in subjects with triphasic mitral inflow velocity pattern with mid-diastolic flow is associated with higher E/E′, elevated proBNP and enlarged left atrium indicating advanced diastolic dysfunction with elevated filling pressures. This unique mitral annular velocity pattern should be helpful in identifying the patients with advanced diastolic dysfunction and increased LV filling pressures.

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