Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery

Kyonghee Park; Goo Young Jung; Myong Ki Kim; Mork Soon Park; Yong Kook Shin; Jae Kwan Hwang; Soon Hong Yuk

doi:10.1007/s13233-012-0123-1

Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery

Kyonghee Park, Goo Young Jung, Myong Ki Kim, Mork Soon Park, Yong Kook Shin, Jae Kwan Hwang, Soon Hong Yuk

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.

Original language	English
Pages (from-to)	847-851
Number of pages	5
Journal	Macromolecular Research
Volume	20
Issue number	8
DOIs	https://doi.org/10.1007/s13233-012-0123-1
Publication status	Published - 2012 Aug

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)
Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1007/s13233-012-0123-1

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title = "Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery",

abstract = "Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.",

author = "Kyonghee Park and Jung, {Goo Young} and Kim, {Myong Ki} and Park, {Mork Soon} and Shin, {Yong Kook} and Hwang, {Jae Kwan} and Yuk, {Soon Hong}",

year = "2012",

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doi = "10.1007/s13233-012-0123-1",

language = "English",

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journal = "Macromolecular Research",

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AU - Park, Kyonghee

AU - Jung, Goo Young

AU - Kim, Myong Ki

AU - Park, Mork Soon

AU - Shin, Yong Kook

AU - Hwang, Jae Kwan

AU - Yuk, Soon Hong

PY - 2012/8

Y1 - 2012/8

N2 - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.

AB - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.

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JO - Macromolecular Research

JF - Macromolecular Research

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Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery

Abstract

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