Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery

Kyonghee Park, Goo Young Jung, Myong Ki Kim, Mork Soon Park, Yong Kook Shin, Jae-Kwan Hwang, Soon Hong Yuk

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.

Original languageEnglish
Pages (from-to)847-851
Number of pages5
JournalMacromolecular Research
Volume20
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

Fingerprint

Triptorelin Pamoate
Controlled drug delivery
Polyglactin 910
Microspheres
Acetates
Mannitol
Acetone
Particle size
Methylene Chloride
Hormones
Dichloromethane
Luteinizing Hormone
polylactic acid-polyglycolic acid copolymer
Peptides
Surface morphology
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Chemical Engineering(all)

Cite this

Park, Kyonghee ; Jung, Goo Young ; Kim, Myong Ki ; Park, Mork Soon ; Shin, Yong Kook ; Hwang, Jae-Kwan ; Yuk, Soon Hong. / Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery. In: Macromolecular Research. 2012 ; Vol. 20, No. 8. pp. 847-851.
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Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery. / Park, Kyonghee; Jung, Goo Young; Kim, Myong Ki; Park, Mork Soon; Shin, Yong Kook; Hwang, Jae-Kwan; Yuk, Soon Hong.

In: Macromolecular Research, Vol. 20, No. 8, 01.08.2012, p. 847-851.

Research output: Contribution to journalArticle

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