Triterpenoid glycosides from the rhizomes of Allium ascalonicum and their anoctamin-1 inhibitory activity

Nguyen Thi Mai, Duong Thi Dung, Tran Thuy Nga, Vu Thi Xuan, Vu Van Doan, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Phan Van Kiem, Yohan Seo, Wan Namkung, Seon Ju Park, Seung Hyun Kim

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1 Citation (Scopus)

Abstract

Ten triterpenoid glycosides including two undescribed compounds (1 and 2) were isolated from the methanol extract of Allium ascalonicum rhizomes. These compounds were structurally elucidated to be 3β-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-19α-hydroxyolean-12-ene-28-oic acid 28-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl] ester (1), 3-O-β-D-glucopyranosyl-(1→3)-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl-3β,19α-dihydroxyoleanane-12-en-28-oic acid (2), lactifoloside C (3), lactifoloside H (4), randiasaponin IV (5), kudinoside G (6), ilexkudinoside W (7), lactifoloside G (8), kudinoside D (9), and ilexkudinoside T (10) by analyzing their HR-ESI-MS, NMR spectral data and by comparison with those reported in the literature. Compounds 1–10 were evaluated for anoctamin-1 (ANO1) inhibitory activity using yellow fluorescent protein reduction assays. At the concentration of 30 µM, compounds 2 and 9 displayed moderate ANO1 inhibitory percentages of 28.9 ± 0.85% and 26.2 ± 0.65%, respectively.

Original languageEnglish
Pages (from-to)4338-4346
Number of pages9
JournalNatural Product Research
Volume35
Issue number22
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2018.332 and by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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