TrkC plays an essential role in breast tumor growth and metastasis

Wook Jin, Gyoung Mi Kim, Min Soo Kim, Mi Hee Lim, Chohee Yun, Joon Jeong, Jeong Seok Nam, Seong Jin Kim

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48 Citations (Scopus)

Abstract

Tropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis. Ectopic expression of TrkC in non-malignant mammary epithelial cells suppressed anoikis, which correlated with activation of the Ras-mitogenactivated protein kinase and phosphatidylinositol-3-OH kinase (PI3K)/Akt pathways, and reduced expression of the metastatic regulator Twist. Furthermore, suppression of TrkC expression in highly metastatic mammary carcinoma cells inhibited their growth in vitro, as well as their ability to metastasize from the mammary gland to the lung in vivo. These results have identified TrkC as a critical regulator of breast cancer cell growth and metastasis.

Original languageEnglish
Pages (from-to)1939-1947
Number of pages9
JournalCarcinogenesis
Volume31
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

All Science Journal Classification (ASJC) codes

  • Cancer Research

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    Jin, W., Kim, G. M., Kim, M. S., Lim, M. H., Yun, C., Jeong, J., Nam, J. S., & Kim, S. J. (2010). TrkC plays an essential role in breast tumor growth and metastasis. Carcinogenesis, 31(11), 1939-1947. https://doi.org/10.1093/carcin/bgq180