TRPC channels

Interacting proteins

K. Kiselyov, DongMin Shin, J. Y. Kim, J. P. Yuan, S. Muallem

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

TRP channels, in particular the TRPC and TRPV subfamilies, have emerged as important constituents of the receptor-activated Ca2+ influx mechanism triggered by hormones, growth factors, and neurotransmitters through activation of phospholipase C (PLC). Several TRPC channels are also activated by passive depletion of endoplasmic reticulum (ER) Ca2+. Although in several studies the native TRP channels faithfully reproduce the respective recombinant channels, more often the properties of Ca2+ entry and/or the store-operated current are strikingly different from that of the TRP channels expressed in the same cells. The present review aims to discuss this disparity in the context of interaction of TRPC channels with auxiliary proteins that may alter the permeation and regulation of TRPC channels.

Original languageEnglish
Title of host publicationTransient Receptor Potential (TRP) Channels
EditorsVeit Flockerzi, Bernd Nilius
Pages559-574
Number of pages16
DOIs
Publication statusPublished - 2007 Dec 1

Publication series

NameHandbook of Experimental Pharmacology
Volume179
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Fingerprint

Hormones
Type C Phospholipases
Permeation
Endoplasmic Reticulum
Neurotransmitter Agents
Intercellular Signaling Peptides and Proteins
Chemical activation
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kiselyov, K., Shin, D., Kim, J. Y., Yuan, J. P., & Muallem, S. (2007). TRPC channels: Interacting proteins. In V. Flockerzi, & B. Nilius (Eds.), Transient Receptor Potential (TRP) Channels (pp. 559-574). (Handbook of Experimental Pharmacology; Vol. 179). https://doi.org/10.1007/978-3-540-34891-7_33
Kiselyov, K. ; Shin, DongMin ; Kim, J. Y. ; Yuan, J. P. ; Muallem, S. / TRPC channels : Interacting proteins. Transient Receptor Potential (TRP) Channels. editor / Veit Flockerzi ; Bernd Nilius. 2007. pp. 559-574 (Handbook of Experimental Pharmacology).
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Kiselyov, K, Shin, D, Kim, JY, Yuan, JP & Muallem, S 2007, TRPC channels: Interacting proteins. in V Flockerzi & B Nilius (eds), Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol. 179, pp. 559-574. https://doi.org/10.1007/978-3-540-34891-7_33

TRPC channels : Interacting proteins. / Kiselyov, K.; Shin, DongMin; Kim, J. Y.; Yuan, J. P.; Muallem, S.

Transient Receptor Potential (TRP) Channels. ed. / Veit Flockerzi; Bernd Nilius. 2007. p. 559-574 (Handbook of Experimental Pharmacology; Vol. 179).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Kiselyov, K.

AU - Shin, DongMin

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AB - TRP channels, in particular the TRPC and TRPV subfamilies, have emerged as important constituents of the receptor-activated Ca2+ influx mechanism triggered by hormones, growth factors, and neurotransmitters through activation of phospholipase C (PLC). Several TRPC channels are also activated by passive depletion of endoplasmic reticulum (ER) Ca2+. Although in several studies the native TRP channels faithfully reproduce the respective recombinant channels, more often the properties of Ca2+ entry and/or the store-operated current are strikingly different from that of the TRP channels expressed in the same cells. The present review aims to discuss this disparity in the context of interaction of TRPC channels with auxiliary proteins that may alter the permeation and regulation of TRPC channels.

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Kiselyov K, Shin D, Kim JY, Yuan JP, Muallem S. TRPC channels: Interacting proteins. In Flockerzi V, Nilius B, editors, Transient Receptor Potential (TRP) Channels. 2007. p. 559-574. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-540-34891-7_33