Tuberculosis

Diagnostics

Sangnae Cho, Patrick J. Brennan

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

While microscopy and culture are still the major backbone for laboratory diagnosis of tuberculosis (TB), new methods including molecular diagnostic tests have evolved over the last two decades. The majority of molecular tests have been focused on: (i) detection of nucleic acids both DNA and RNA, which are specific to Mycobacterium tuberculosis, by amplification techniques such as polymerase chain reaction (PCR); and (ii) detection of mutations in the genes which are associated with resistance to anti-tuberculosis drugs by sequencing or nucleic acid hybridization. In the session of the conference on diagnosis of TB, there were two presentations: one on the development of new diagnostic tools for drug resistant M. tuberculosis, and the other on issues involved in the application of new diagnostic tools for multidrug resistant (MDR)-TB, pediatric TB and HIV-TB.

Original languageEnglish
JournalTuberculosis
Volume87
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2007 Aug 1

Fingerprint

tuberculosis
Tuberculosis
Multidrug-Resistant Tuberculosis
Mycobacterium tuberculosis
Nucleic Acid Hybridization
Molecular Pathology
Clinical Laboratory Techniques
drugs
Mycobacterium
Routine Diagnostic Tests
Nucleic Acids
Microscopy
nucleic acid hybridization
diagnostic techniques
nucleic acids
HIV
RNA
microscopy
Pediatrics
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cho, Sangnae ; Brennan, Patrick J. / Tuberculosis : Diagnostics. In: Tuberculosis. 2007 ; Vol. 87, No. SUPPL. 1.
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Tuberculosis : Diagnostics. / Cho, Sangnae; Brennan, Patrick J.

In: Tuberculosis, Vol. 87, No. SUPPL. 1, 01.08.2007.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Tuberculosis

T2 - Diagnostics

AU - Cho, Sangnae

AU - Brennan, Patrick J.

PY - 2007/8/1

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AB - While microscopy and culture are still the major backbone for laboratory diagnosis of tuberculosis (TB), new methods including molecular diagnostic tests have evolved over the last two decades. The majority of molecular tests have been focused on: (i) detection of nucleic acids both DNA and RNA, which are specific to Mycobacterium tuberculosis, by amplification techniques such as polymerase chain reaction (PCR); and (ii) detection of mutations in the genes which are associated with resistance to anti-tuberculosis drugs by sequencing or nucleic acid hybridization. In the session of the conference on diagnosis of TB, there were two presentations: one on the development of new diagnostic tools for drug resistant M. tuberculosis, and the other on issues involved in the application of new diagnostic tools for multidrug resistant (MDR)-TB, pediatric TB and HIV-TB.

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