Abstract
While microscopy and culture are still the major backbone for laboratory diagnosis of tuberculosis (TB), new methods including molecular diagnostic tests have evolved over the last two decades. The majority of molecular tests have been focused on: (i) detection of nucleic acids both DNA and RNA, which are specific to Mycobacterium tuberculosis, by amplification techniques such as polymerase chain reaction (PCR); and (ii) detection of mutations in the genes which are associated with resistance to anti-tuberculosis drugs by sequencing or nucleic acid hybridization. In the session of the conference on diagnosis of TB, there were two presentations: one on the development of new diagnostic tools for drug resistant M. tuberculosis, and the other on issues involved in the application of new diagnostic tools for multidrug resistant (MDR)-TB, pediatric TB and HIV-TB.
| Original language | English |
|---|---|
| Journal | Tuberculosis |
| Volume | 87 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2007 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Microbiology (medical)
- Infectious Diseases
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Tuberculosis : Diagnostics. / Cho, Sangnae; Brennan, Patrick J.
In: Tuberculosis, Vol. 87, No. SUPPL. 1, 01.08.2007.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Tuberculosis
T2 - Diagnostics
AU - Cho, Sangnae
AU - Brennan, Patrick J.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - While microscopy and culture are still the major backbone for laboratory diagnosis of tuberculosis (TB), new methods including molecular diagnostic tests have evolved over the last two decades. The majority of molecular tests have been focused on: (i) detection of nucleic acids both DNA and RNA, which are specific to Mycobacterium tuberculosis, by amplification techniques such as polymerase chain reaction (PCR); and (ii) detection of mutations in the genes which are associated with resistance to anti-tuberculosis drugs by sequencing or nucleic acid hybridization. In the session of the conference on diagnosis of TB, there were two presentations: one on the development of new diagnostic tools for drug resistant M. tuberculosis, and the other on issues involved in the application of new diagnostic tools for multidrug resistant (MDR)-TB, pediatric TB and HIV-TB.
AB - While microscopy and culture are still the major backbone for laboratory diagnosis of tuberculosis (TB), new methods including molecular diagnostic tests have evolved over the last two decades. The majority of molecular tests have been focused on: (i) detection of nucleic acids both DNA and RNA, which are specific to Mycobacterium tuberculosis, by amplification techniques such as polymerase chain reaction (PCR); and (ii) detection of mutations in the genes which are associated with resistance to anti-tuberculosis drugs by sequencing or nucleic acid hybridization. In the session of the conference on diagnosis of TB, there were two presentations: one on the development of new diagnostic tools for drug resistant M. tuberculosis, and the other on issues involved in the application of new diagnostic tools for multidrug resistant (MDR)-TB, pediatric TB and HIV-TB.
UR - http://www.scopus.com/inward/record.url?scp=34547655417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547655417&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2007.05.001
DO - 10.1016/j.tube.2007.05.001
M3 - Review article
VL - 87
JO - Tuberculosis
JF - Tuberculosis
SN - 1472-9792
IS - SUPPL. 1
ER -