Tubuloreticular inclusions in peritubular capillaries of renal allografts

Jee Youn Lee, Seung Hwan Song, Yu Seun Kim, Beom Jin Lim, Soon Il Kim, Myoung Soo Kim, Hyeon Joo Jeong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Tubuloreticular inclusions (TRIs) are anastomosing networks of microtubules that are frequently found in autoimmune diseases and viral infections. In renal allografts, TRIs have been reported in glomerular endothelial cells in association with viral infections and donor specific antibodies (DSAs), but their presence in peritubular capillaries has not been explored. Methods We collected seven cases with TRIs out of 148 consecutive renal allograft biopsies taken from Dec. 2015 to Dec. 2016. Results TRIs were present in peritubular capillaries in seven cases and were concomitantly present in glomerular endothelial cells in two cases. The diagnoses included polyomavirus nephropathy (n = 2), acute T cell-mediated rejection (ACR) (n = 1), combined ACR and antibody-mediated rejection (AMR) (n = 1), suspicious for ACR (n = 1), chronic active AMR (n = 1), and moderate tubular atrophy and interstitial fibrosis (n = 1). Six patients had recent or current viral infections (BK polyomavirus, hepatitis B virus, herpes simplex virus, and cytomegalovirus in two, two, one, and one case, respectively). DSA was positive in one case. Five cases had moderate to severe interstitial inflammation and four cases had peritubular capillaritis. Conclusion TRIs are not rare in peritubular capillaries. They are associated with various viral infections and their appearance seems to be related to peritubular capillary injury.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalPathology Research and Practice
Volume213
Issue number9
DOIs
Publication statusPublished - 2017 Sep

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Virus Diseases
Allografts
Kidney
Antibodies
T-Lymphocytes
Endothelial Cells
Tissue Donors
BK Virus
Polyomavirus
Simplexvirus
Cytomegalovirus
Hepatitis B virus
Microtubules
Autoimmune Diseases
Atrophy
Fibrosis
Inflammation
Biopsy
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Lee, J. Y., Song, S. H., Kim, Y. S., Lim, B. J., Kim, S. I., Kim, M. S., & Jeong, H. J. (2017). Tubuloreticular inclusions in peritubular capillaries of renal allografts. Pathology Research and Practice, 213(9), 1185-1190. https://doi.org/10.1016/j.prp.2017.06.009
Lee, Jee Youn ; Song, Seung Hwan ; Kim, Yu Seun ; Lim, Beom Jin ; Kim, Soon Il ; Kim, Myoung Soo ; Jeong, Hyeon Joo. / Tubuloreticular inclusions in peritubular capillaries of renal allografts. In: Pathology Research and Practice. 2017 ; Vol. 213, No. 9. pp. 1185-1190.
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Tubuloreticular inclusions in peritubular capillaries of renal allografts. / Lee, Jee Youn; Song, Seung Hwan; Kim, Yu Seun; Lim, Beom Jin; Kim, Soon Il; Kim, Myoung Soo; Jeong, Hyeon Joo.

In: Pathology Research and Practice, Vol. 213, No. 9, 09.2017, p. 1185-1190.

Research output: Contribution to journalArticle

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T1 - Tubuloreticular inclusions in peritubular capillaries of renal allografts

AU - Lee, Jee Youn

AU - Song, Seung Hwan

AU - Kim, Yu Seun

AU - Lim, Beom Jin

AU - Kim, Soon Il

AU - Kim, Myoung Soo

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N2 - Background Tubuloreticular inclusions (TRIs) are anastomosing networks of microtubules that are frequently found in autoimmune diseases and viral infections. In renal allografts, TRIs have been reported in glomerular endothelial cells in association with viral infections and donor specific antibodies (DSAs), but their presence in peritubular capillaries has not been explored. Methods We collected seven cases with TRIs out of 148 consecutive renal allograft biopsies taken from Dec. 2015 to Dec. 2016. Results TRIs were present in peritubular capillaries in seven cases and were concomitantly present in glomerular endothelial cells in two cases. The diagnoses included polyomavirus nephropathy (n = 2), acute T cell-mediated rejection (ACR) (n = 1), combined ACR and antibody-mediated rejection (AMR) (n = 1), suspicious for ACR (n = 1), chronic active AMR (n = 1), and moderate tubular atrophy and interstitial fibrosis (n = 1). Six patients had recent or current viral infections (BK polyomavirus, hepatitis B virus, herpes simplex virus, and cytomegalovirus in two, two, one, and one case, respectively). DSA was positive in one case. Five cases had moderate to severe interstitial inflammation and four cases had peritubular capillaritis. Conclusion TRIs are not rare in peritubular capillaries. They are associated with various viral infections and their appearance seems to be related to peritubular capillary injury.

AB - Background Tubuloreticular inclusions (TRIs) are anastomosing networks of microtubules that are frequently found in autoimmune diseases and viral infections. In renal allografts, TRIs have been reported in glomerular endothelial cells in association with viral infections and donor specific antibodies (DSAs), but their presence in peritubular capillaries has not been explored. Methods We collected seven cases with TRIs out of 148 consecutive renal allograft biopsies taken from Dec. 2015 to Dec. 2016. Results TRIs were present in peritubular capillaries in seven cases and were concomitantly present in glomerular endothelial cells in two cases. The diagnoses included polyomavirus nephropathy (n = 2), acute T cell-mediated rejection (ACR) (n = 1), combined ACR and antibody-mediated rejection (AMR) (n = 1), suspicious for ACR (n = 1), chronic active AMR (n = 1), and moderate tubular atrophy and interstitial fibrosis (n = 1). Six patients had recent or current viral infections (BK polyomavirus, hepatitis B virus, herpes simplex virus, and cytomegalovirus in two, two, one, and one case, respectively). DSA was positive in one case. Five cases had moderate to severe interstitial inflammation and four cases had peritubular capillaritis. Conclusion TRIs are not rare in peritubular capillaries. They are associated with various viral infections and their appearance seems to be related to peritubular capillary injury.

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